Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes

被引:0
作者
Kong, Cherrie H. T. [1 ]
Dries, Eef [2 ]
机构
[1] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Bristol, England
[2] Katholieke Univ Leuven, Dept Cardiovasc Sci, Lab Expt Cardiol, Leuven, Belgium
关键词
REM; FAMILY; GEM; MEMBER;
D O I
10.1085/jgp.202413629
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Rad is an emerging key Ca-v1.2 modulator. In the present issue of JGP, Elmore, Ahern et al. examine how the Rad C-terminus affects its subcellular distribution and Ca-v1.2 regulation.
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页数:4
相关论文
共 29 条
[1]   Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice [J].
Ahern, Brooke M. ;
Levitan, Bryana M. ;
Veeranki, Sudhakar ;
Shah, Mihir ;
Ali, Nemat ;
Sebastian, Andrea ;
Su, Wen ;
Gong, Ming C. ;
Li, Jiayang ;
Stelzer, Julian E. ;
Andres, Douglas A. ;
Satin, Jonathan .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (28) :10913-10927
[2]   Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem [J].
Béguin, P ;
Nagashima, K ;
Gonoi, T ;
Shibasaki, T ;
Takahashi, K ;
Kashima, Y ;
Ozaki, N ;
Geering, T ;
Iwanaga, T ;
Seino, S .
NATURE, 2001, 411 (6838) :701-706
[3]   L-type Ca2+ current in ventricular cardiomyocytes [J].
Benitah, Jean-Pierre ;
Alvarez, Julio L. ;
Gomez, Ana Maria .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2010, 48 (01) :26-36
[4]   Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes [J].
Best, Jabe M. ;
Kamp, Timothy J. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (02) :376-387
[5]   The Ras-related protein Rad associates with the cytoskeleton in a non-lipid-dependent manner [J].
Bilan, PJ ;
Moyers, JS ;
Kahn, CR .
EXPERIMENTAL CELL RESEARCH, 1998, 242 (02) :391-400
[6]   Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular ICa density in mouse ventricular myocytes [J].
Bryant, Simon M. ;
Kong, Cherrie H. T. ;
Watson, Judy J. ;
Gadeberg, Hanne C. ;
Roth, David M. ;
Patel, Hemal H. ;
Cannell, Mark B. ;
James, O. Andrew F. ;
Orchard, Clive H. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018, 315 (05) :H1101-H1111
[7]   Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K+ channels for atrial fibrillation treatment [J].
Burg, Shira ;
Shapiro, Shir ;
Peretz, Asher ;
Haimov, Elvira ;
Redko, Boris ;
Yeheskel, Adva ;
Simhaev, Luba ;
Engel, Hamutal ;
Raveh, Avi ;
Ben-Bassat, Ariel ;
Murninkas, Michael ;
Polak, Rotem ;
Haitin, Yoni ;
Etzion, Yoram ;
Attali, Bernard .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (34)
[8]   Rad GTPase deficiency leads to cardiac hypertrophy [J].
Chang, Lin ;
Zhang, Jifeng ;
Tseng, Yu-Hua ;
Xie, Chang-Qing ;
Ilany, Jacob ;
Bruning, Jens C. ;
Sun, Zhongcui ;
Zhu, Xiaojun ;
Cui, Taixing ;
Youker, Keith A. ;
Yang, Qinglin ;
Day, Sharlene M. ;
Kahn, C. Ronald ;
Chen, Y. Eugene .
CIRCULATION, 2007, 116 (25) :2976-2983
[9]   Designer genetically encoded voltage-dependent calcium channel inhibitors inspired by RGK GTPases [J].
Colecraft, Henry M. .
JOURNAL OF PHYSIOLOGY-LONDON, 2020, 598 (09) :1683-1693
[10]   Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition [J].
Correll, Robert N. ;
Pang, Chunyan ;
Finlin, Brian S. ;
Dailey, Alexandria M. ;
Satin, Jonathan ;
Andres, Douglas A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (39) :28431-28440