Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls

被引：2
作者：
Wannan, Cassandra M. J. [1 ,2 ,3 ]
Eratne, Dhamidhu [1 ,4 ]
Santillo, Alexander F. [5 ]
Malpas, Charles [6 ,7 ]
Cilia, Brandon [4 ]
Dean, Olivia M. [8 ,9 ]
Walker, Adam [8 ]
Berk, Michael [8 ]
Bousman, Chad [10 ,11 ]
Everall, Ian [12 ]
Velakoulis, Dennis [1 ,4 ]
Pantelis, Christos [1 ,13 ,14 ,15 ]
机构：
[1] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Melbourne, Vic, Australia
[2] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia
[3] Orygen, Parkville, Vic, Australia
[4] Royal Melbourne Hosp, Neuropsychiat Ctr, Melbourne, Vic, Australia
[5] Lund Univ, Fac Med, Dept Clin Sci, Clin Memory Res Unit, Lund, Sweden
[6] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Australia
[7] Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Australia
[8] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Australia
[9] Florey Inst Neurosci & Mental Hlth, Parkville, Australia
[10] Univ Calgary, Dept Med Genet, Calgary, AB, Canada
[11] Univ Melbourne, Dept Psychiat, Melbourne, Australia
[12] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
[13] Univ Melbourne, Western Ctr Hlth Res & Educ, St Albans, Vic, Australia
[14] Sunshine Hosp, Western Hlth, St Albans, Vic, Australia
[15] Monash Univ, Monash Inst Pharmaceut Sci MIPS, Parkville, Vic, Australia
来源：
PSYCHIATRY RESEARCH | 2024年 / 339卷
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Neurofilament; Psychiatry; Psychiatric disorders; Bipolar; Depression; Schizophrenia; Accelerated aging; MAJOR DEPRESSIVE DISORDER; CHAIN;
D O I：
10.1016/j.psychres.2024.116073
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.
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页数：5
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