Tumor spread through air spaces in lung cancer: prospective analysis of the accuracy of intraoperative frozen section examination

被引:0
|
作者
de Almeida, Germano Luciano [1 ]
Pinto, Bruno Maineri [1 ]
Pinto, Vitor Maineri [1 ]
Tregnago, Aline Caldart [1 ]
Almeida, Renata Fragomeni [1 ]
Pinto Filho, Darcy Ribeiro [1 ]
机构
[1] Univ Caxias Do Sul, Hosp Geral Caxias Do Sul, Caxias Do Sul, RS, Brazil
关键词
Neoplasm invasiveness; Frozen sections; Lung neoplasms/pathology; Lung neoplasms/surgery; STAS; RECURRENCE; IMPACT; RESECTION; PATTERN;
D O I
10.36416/1806-3756/e20240165
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Objective: To establish the accuracy of frozen section examination in identifying tumor spread through air spaces (STAS), as well as to propose a reproducible technical methodology for frozen section analysis. We also aim to propose a method to be incorporated into the decision making about the need for conversion to lobectomy during sublobar resection. Methods: This was a nonrandomized prospective study of 38 patients with lung cancer who underwent surgical resection. The findings regarding STAS in the frozen section were compared with the definitive histopathological study of paraffin-embedded sections. We calculated a confusion matrix to obtain the positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity and accuracy. Results: The intraoperative frozen section analysis identified 7 STAS-positive cases that were also positive in the histopathological examination, as well as 3 STAS-negative cases that were positive in the in the histopathological examination. Therefore, frozen section analysis was determined to have a sensitivity of 70%, specificity of 100%, PPV of 100%, NPV of 90.3%, and accuracy of 92% for identifying STAS. Conclusions: Frozen section analysis is capable of identifying STAS during resection in patients with lung cancer. The PPV, NPV, sensitivity, and specificity showed that the technique proposed could be incorporated at other centers and would allow advances directly linked to prognosis. In addition, given the high accuracy of the technique, it could inform intraoperative decisions regarding sublobar versus lobar resection.
引用
收藏
页数:7
相关论文
共 50 条
  • [21] Current Evidence Does Not Warrant Frozen Section Evaluation for the Presence of Tumor Spread Through Alveolar Spaces
    Walts, Ann E.
    Marchevsky, Alberto M.
    ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2018, 142 (01) : 59 - 63
  • [22] Preoperative bronchial cytology for the assessment of tumor spread through air spaces in lung adenocarcinoma resection specimens
    Medina, Mayra A.
    Onken, Allison M.
    de Margerie-Mellon, Constance
    Heidinger, Benedikt H.
    Chen, Yigu
    Bankier, Alexander A.
    VanderLaan, Paul A.
    CANCER CYTOPATHOLOGY, 2020, 128 (04) : 278 - 286
  • [23] Radiomics is feasible for prediction of spread through air spaces in patients with nonsmall cell lung cancer
    Onozato, Yuki
    Nakajima, Takahiro
    Yokota, Hajime
    Morimoto, Jyunichi
    Nishiyama, Akira
    Toyoda, Takahide
    Inage, Terunaga
    Tanaka, Kazuhisa
    Sakairi, Yuichi
    Suzuki, Hidemi
    Uno, Takashi
    Yoshino, Ichiro
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [24] Updates on spread through air spaces (STAS) in lung cancer
    Shih, Angela R.
    Mino-Kenudson, Mari
    HISTOPATHOLOGY, 2020, 77 (02) : 173 - 180
  • [25] Impact of the distance of spread through air spaces in non-small cell lung cancer
    Hashinokuchi, Asato
    Akamine, Takaki
    Toyokawa, Gouji
    Matsudo, Kyoto
    Nagano, Taichi
    Kinoshita, Fumihiko
    Kohno, Mikihiro
    Tomonaga, Takumi
    Kohashi, Kenichi
    Shimokawa, Mototsugu
    Oda, Yoshinao
    Takenaka, Tomoyoshi
    Yoshizumi, Tomoharu
    INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY, 2024, 40 (01):
  • [26] Correlation between spread through air spaces (STAS) and other clinicopathological parameters in lung cancer
    Moreno, Juan Carlos Alvarez
    Aljamal, Abed Alhalim
    Bahmad, Hisham F.
    Febres-Aldana, Christopher A.
    Rassaei, Negar
    Recine, Monica
    Poppiti, Robert
    PATHOLOGY RESEARCH AND PRACTICE, 2021, 220
  • [27] Lung neuroendocrine tumors: a new addition to the evolving list of spread through air spaces
    Uruga, Hironori
    Mino-Kenudson, Mari
    TRANSLATIONAL LUNG CANCER RESEARCH, 2019, 8 : S443 - S446
  • [28] Taking the measure of lung adenocarcinoma: towards a quantitative approach to tumor spread through air spaces (STAS)
    Morales-Oyarvide, Vicente
    Mino-Kenudson, Mari
    JOURNAL OF THORACIC DISEASE, 2017, 9 (09) : 2756 - 2761
  • [29] Is Spread of Tumor through Air Spaces a Concern for Interpreting Lung Nodules on CT Images?
    Naidich, David P.
    RADIOLOGY, 2018, 289 (03) : 841 - 842
  • [30] Relationship between stromal cells and tumor spread through air spaces in lung adenocarcinoma
    Qiu, Xie
    Chen, Donglai
    Liu, Yangyang
    Duan, Shanzhou
    Zhang, Fuquan
    Zhang, Yongsheng
    Li, Feng
    Chen, Chang
    Chen, Yongbing
    THORACIC CANCER, 2019, 10 (02) : 256 - 267