Isoimperatorin alleviates acetic acid-induced colitis in rats

被引：1

作者：

Goodarzi, Saied ^{[1
]}

Abdolghaffari, Amir Hossein ^{[2
]}

Najafi, Behnaz ^{[3
]}

Hamedani, Mostafa Pirali ^{[3
]}

Tavakoli, Saeed ^{[4
]}

Marvi, Mahshad ^{[5
]}

Baeeri, Maryam ^{[6
]}

Yassa, Narguess ^{[3
]}

Hadjiakhoondi, Abbas ^{[1
,3
]}

Abdollahi, Mohammad ^{[6
,7
]}

Tofighi, Zahra ^{[1
,3
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Med Plants Res Ctr, Tehran, Iran

[2] Islamic Azad Univ, Fac Pharm, Dept Toxicol & Pharmacol, Tehran Med Sci, Tehran, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Pharmacognosy, Tehran, Iran

[4] ACECR, Inst Med Plants, Med Plants Res Ctr, Karaj, Iran

[5] Univ Tehran Med Sci, Int Campus Sch Pharm, Tehran, Iran

[6] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Toxicol & Dis Grp, Tehran, Iran

[7] Univ Tehran Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Tehran, Iran

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE | 2024年 / 14卷 / 04期

关键词：

Isoimperatorin; Inflammatory bowel disease; Acetic acid; Colitis; TNF-alpha; IL-1; beta; INFLAMMATORY-BOWEL-DISEASE; TNF-ALPHA; IN-VIVO; COUMARINS; INTERLEUKIN-1; PATHOGENESIS; INVOLVEMENT; EXPRESSION; MICROBIOTA; SEVERITY;

D O I：

10.4103/apjtb.apjtb_851_23

中图分类号：

R188.11 [热带医学];

学科分类号：

摘要：

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats.Methods:Colitis was induced by intracolonic administration of acetic acid solution (4% v/v) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses.Results:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-alpha, IL-1 beta, and malodialdehyde levels.Conclusions:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

引用

页码：147 / 153

页数：7

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