Lower Rates of Staphylococcus aureus Bloodstream Infection in Patients on Hemodialysis Receiving Trimethoprim-Sulfamethoxazole Melioidosis Prophylaxis

被引:4
作者
Bryce, Aliya [1 ,2 ]
Davison, Sara [1 ]
Currie, Bart J. [1 ,3 ]
Birrell, Johanna M. [4 ]
Baird, Robert W. [1 ]
Abeyaratne, Asanga [3 ,5 ,6 ,7 ]
Majoni, Sandawana William [3 ,5 ,6 ,7 ]
Brewster-O'Brien, Teana [5 ]
Tong, Steven Y. C. [8 ,9 ]
机构
[1] Royal Darwin Hosp, Dept Infect Dis, Darwin, NT, Australia
[2] Royal Melbourne Hosp, Dept Gen Med, 300 Grattan St, Melbourne, Vic 3052, Australia
[3] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, Australia
[4] NT Hlth, Northern Terr Ctr Dis Control, Darwin, NT, Australia
[5] Royal Darwin Hosp, Dept Nephrol, Darwin, NT, Australia
[6] Flinders Univ S Australia, Darwin, NT, Australia
[7] Royal Darwin Hosp Campus, Northern Terr Med Program, Darwin, NT, Australia
[8] Royal Melbourne Hosp, Peter Doherty Inst Infect & Immun, Victorian Infect Dis Serv, Melbourne, Vic, Australia
[9] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Infect Dis, Melbourne, Vic, Australia
关键词
antibiotic prophylaxis; bloodstream infection; hemodialysis; Staphylococcus aureus; trimethoprim-sulfamethoxazole; RISK; BACTEREMIA;
D O I
10.1093/ofid/ofae431
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Hemodialysis is a risk factor for Staphylococcus aureus bloodstream infection (SAB). In this single-center study, SAB rates were 56% lower during the monsoonal wet season when patients on hemodialysis receive supervised melioidosis prophylaxis with trimethoprim-sulfamethoxazole. This intervention may reduce SAB rates in high-risk patients; however, further targeted studies are required. Graphical abstract https://tidbitapp.io/institutional-portal/open-forum-infectious-diseases/tidbits/lower-rates-of-staphylococcus-aureus-bloodstream-infection-in-patients-on-hemodialysis-receiving-trimethoprim-sulfamethoxazole-melioidosis-prophylaxis/update In the Northern Territory of Australia, patients on hemodialysis receive seasonal post-dialysis Trimethoprim-Sulfamethoxazole as melioidosis prophylaxis. This single-center study explored the effect of this intervention on rates of Staphylococcus Aureus bloodstream infections in this high risk group.
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页数:4
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