Long noncoding RNA MEG3: an active player in fibrosis

被引:0
作者
Jiang, Xiaoying [1 ]
机构
[1] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
基金
美国国家科学基金会;
关键词
Fibrosis; Long noncoding RNAs; MEG3; Potential target; STELLATE CELLS ACTIVATION; DIABETIC-NEPHROPATHY; CARDIAC FIBROSIS;
D O I
10.1007/s43440-024-00661-x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Fibrosis, characterized by excess accumulation of extracellular matrix components, disrupts normal tissue structure and causes organ dysfunction. Long noncoding RNAs (lncRNAs) are a subset of RNAs longer than 200 nucleotides that are not converted into proteins. The increasing research indicated that lncRNA maternally expressed gene 3 (MEG3) was dysregulated in the pathologic process of fibrosis in several tissues. LncRNA MEG3 was revealed to regulate the expression of target proteins or serve as a miRNAs sponge to control the development of fibrosis, which was involved in NF-kappa B, PI3K/AKT, JAK2/STAT3, Wnt/beta-catenin, ERK/p38, and Hh pathway. Importantly, the interference of MEG3 level ameliorated fibrosis. The present review summarized available studies of lncRNA MEG3 in fibrosis, which is helpful for a deeper understanding of the roles of MEG3 in fibrosis.
引用
收藏
页码:21 / 30
页数:10
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  • [1] MEG3: an Oncogenic Long Non-coding RNA in Different Cancers
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  • [2] Fibrosis and Hepatocarcinogenesis: Role of Gene-Environment Interactions in Liver Disease Progression
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    Farci, Patrizia
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    Joshkon, Ahmad
    Heim, Xavier
    Bachelier, Richard
    Bardin, Nathalie
    Leroyer, Aurelie S.
    Blot-Chabaud, Marcel
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  • [4] Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver
    Bian, Er-Bao
    Wang, Yuan-Yuan
    Yang, Yang
    Wu, Bao-Ming
    Xu, Tao
    Meng, Xiao-Ming
    Huang, Cheng
    Zhang, Lei
    Lv, Xiong-Wen
    Xiong, Zhi-Gang
    Li, Jun
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (03): : 674 - 686
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    Xie, Kewei
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    Yan, Jiayi
    Shao, Xinghua
    Ni, Zhaohui
    Ying, Liang
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    Goh, Nicole
    Hopkins, Peter
    Macansh, Sacha
    Walters, E. Haydn
    Palmer, Andrew J.
    [J]. EUROPEAN JOURNAL OF HEALTH ECONOMICS, 2023, 24 (07) : 1121 - 1139
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    Di Mauro, Stefania
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    Filippello, Agnese
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    Gili, Elisa
    Scionti, Francesca
    Purrazzo, Giacomo
    Di Pino, Antonino
    Scicali, Roberto
    Di Martino, Maria Teresa
    Malaguarnera, Roberta
    Malatino, Lorenzo
    Purrello, Francesco
    Vancheri, Carlo
    Piro, Salvatore
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (22) : 1 - 12
  • [9] Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options: An Update
    Duspara, Kristina
    Bojanic, Kristina
    Pejic, Josipa Ivanusic
    Kuna, Lucija
    Kolaric, Tea Omanovic
    Nincevic, Vjera
    Smolic, Robert
    Vcev, Aleksandar
    Glasnovic, Marija
    Curcic, Ines Bilic
    Smolic, Martina
    [J]. JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2021, 9 (06) : 960 - 971
  • [10] TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling
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    Brook, Elizabetha
    Bardenstein-Wald, Becky
    Shitrit, David
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