Advances in eicosanoid research, novel therapeutic implications

被引：89
作者：
Haeggstrom, Jesper Z. [1 ]
Rinaldo-Matthis, Agnes [1 ]
Wheelock, Craig E. [1 ]
Wetterholm, Anders [1 ]
机构：
[1] Karolinska Inst, Div Chem 2, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 396卷 / 01期
基金：
瑞典研究理事会;
关键词：
Eicosanoids; Leukotriene; Inflammation; Asthma; Atherosclerosis; Drug design; LEUKOTRIENE A(4) HYDROLASE; CYTOSOLIC PHOSPHOLIPASE A(2); PROSTAGLANDIN-E SYNTHASE-1; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; RECEPTOR; 5-LIPOXYGENASE; EXPRESSION; INHIBITORS; MEDIATORS;
D O I：
10.1016/j.bbrc.2010.03.140
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eicosanoids are a family of oxygenated metabolites of arachidonic acid, including the prostaglandins, thromboxanes, leukotrienes and lipoxins. These lipid mediators play essential roles in normal cellular homeostasis as well as in a number of disease states. This review will focus on recent advances in the field of eicosanoids and highlight specific discoveries and achievements. Emphasis will be placed on structure and receptor biology, which are of significant pharmacological and clinical relevance. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：135 / 139
页数：5
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