The epigenetic mechanism of metabolic risk in bipolar disorder

被引：0

作者：

Huang, Kexin ^{[1
]}

Li, Sujuan ^{[1
]}

Yang, Min ^{[1
]}

Teng, Ziwei ^{[1
]}

Xu, Baoyan ^{[1
,2
]}

Wang, Bolun ^{[3
]}

Chen, Jindong ^{[1
]}

Zhao, Liping ^{[4
]}

Wu, Haishan ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, China Natl Technol Inst Mental Disorders, Dept Psychiat,Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China

[2] Hebei Univ, Clin Med Coll 6, Hebei Prov Mental Hlth Ctr, Hebei Key Lab Major Mental & Behav Disorders,Dept, Baoding, Hebei, Peoples R China

[3] Cent South Univ, Second Xiangya Hosp, Dept Radiol, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Second Xiangya Hosp, Clin Nursing Teaching & Res Sect, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China

来源：

OBESITY REVIEWS | 2024年 / 25卷 / 11期

基金：

中国国家自然科学基金;

关键词：

bipolar disorder; epigenetics; metabolic syndrome; DNA METHYLATION; INSULIN-RESISTANCE; MOOD STABILIZERS; LIPID-METABOLISM; SCHIZOPHRENIA; EXPRESSION; ASSOCIATION; ANTIPSYCHOTICS; DYSREGULATION; CLOCK;

D O I：

10.1111/obr.13816

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bipolar disorder (BD) is a complex and severe mental illness that causes significant suffering to patients. In addition to the burden of depressive and manic symptoms, patients with BD are at an increased risk for metabolic syndrome (MetS). MetS includes factors associated with an increased risk of atherosclerotic cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), which may increase the mortality rate of patients with BD. Several studies have suggested a link between BD and MetS, which may be explained at an epigenetic level. We have focused on epigenetic mechanisms to review the causes of metabolic risk in BD.

引用

页数：13

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