The Role of Natural Killer Cells in Oncolytic Virotherapy: Friends or Foes?

被引：2

作者：

Franks, Michael L. ^{[1
,2
]}

An, Ju-Hyun ^{[1
]}

Leavenworth, Jianmei W. ^{[1
,3
,4
]}

机构：

[1] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL 35233 USA

[2] Univ Alabama Birmingham, Grad Biomed Sci Program, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, ONeal Comprehens Canc Ctr, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

VACCINES | 2024年 / 12卷 / 07期

关键词：

oncolytic virotherapy; oncolytic virus; natural killer cells; antiviral response; antitumor response; HERPES-SIMPLEX-VIRUS; MHC CLASS-I; VESICULAR STOMATITIS-VIRUS; HUMAN DENDRITIC CELLS; HEAT-SHOCK PROTEINS; NK CELLS; IFN-GAMMA; CANCER-IMMUNOTHERAPY; T-CELLS; TALIMOGENE LAHERPAREPVEC;

D O I：

10.3390/vaccines12070721

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oncolytic virotherapy (OVT) has emerged as a promising cancer immunotherapy, and is capable of potentiating other immunotherapies due to its capacity to increase tumor immunogenicity and to boost host antitumor immunity. Natural killer (NK) cells are a critical cellular component for mediating the antitumor response, but hold a mixed reputation for their role in mediating the therapeutic efficacy of OVT. This review will discuss the pros and cons of how NK cells impact OVT, and how to harness this knowledge for the development of effective strategies that could modulate NK cells to improve OVT-based therapeutic outcomes.

引用

页数：24

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