How Protein Ubiquitination Can Influence Cytokine Expression-Updated Review on Autoinflammatory VEXAS Syndrome

被引:0
作者
Majer, Dominika [1 ]
Kujawinska, Matylda [1 ]
Limanowka, Piotr [2 ]
Sedek, Lukasz [3 ]
机构
[1] Med Univ Silesia, Dept Microbiol & Immunol, Student Res Grp Microbiol & Immunol, Jordana 19, PL-41800 Zabrze, Poland
[2] Med Univ Silesia, Dept Med & Mol Biol, Student Res Grp Med & Mol Biol, Jordana 19, PL-41800 Zabrze, Poland
[3] Med Univ Silesia, Dept Microbiol & Immunol, Jordana 19, Zabrze, Poland
来源
IMMUNO | 2024年 / 4卷 / 03期
关键词
VEXAS; cytokines; ubiquitination; autoinflammation; ACTIVATING ENZYME UBA1; E1; MUTATIONS;
D O I
10.3390/immuno4030018
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
VEXAS syndrome is a new disease entity with symptoms that can mimic hematological, rheumatic and dermatological diseases. It is important to take a multidisciplinary approach to patient care, taking into account genetic testing, in which the presence of mutations in the UBA1 gene can confirm the diagnosis. UBA1 mutation has been shown to be involved in the induction of the inflammatory response through many different mechanisms. NF-kappa B and TNF-alpha pathways appear to be the most important in VEXAS syndrome. There are many different UBA1 mutations which can result in different outcomes, suggesting it is a possible prognostic factor. Furthermore, mutations differ in how they impair UBA1 function. Cytokines have been shown to be significantly altered in VEXAS patients; however, their exact expression and importance were not clearly defined. Interleukins, such as interleukin (IL)-6, IL-1, IL-2R and others, were reported to be expressed at an altered level, similarly to other cytokines, such as IFN-gamma or TNF-alpha. It is worth noting that the expression of certain cytokines can vary between patients, which poses therapeutic difficulties in selecting the right drug. Therefore, the aim of this review was to describe the cytokines involved in VEXAS syndrome and associate their expression with UBA1 mutation.
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收藏
页码:286 / 300
页数:15
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