Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

被引：9

作者：

Wu, Yueming ^{[1
,2
]}

Chen, Kang ^{[1
]}

Wang, Jiangzhou ^{[1
]}

Chen, Minzhang ^{[1
]}

Dai, Wenhui ^{[1
]}

Liu, Runhui ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol, Minist Educ, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Key Lab Specially Funct Poly, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 35期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINO-ACIDS; PHOSGENE-FREE SYNTHESIS; FACILE SYNTHESIS; PRECISION SYNTHESIS; BLOCK-COPOLYMERS; MOLECULAR-WEIGHT; FAST KINETICS; FUNCTIONALIZATION; COPOLYPEPTIDES; DERIVATIVES;

D O I：

10.1021/jacs.4c05382

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides (NCA) ring-opening polymerization has been the most efficient strategy for polypeptide preparation, with continuous advance in the design of initiators, catalysts and reaction conditions. This Perspective first summarizes the recent progress of NCA synthesis and purification. Subsequently, we focus on various initiators for NCA polymerization, catalysts for accelerating polymerization or enhancing the controllability of polymerization, and recent advances in the reaction approach of NCA polymerization. Finally, we discuss future research directions and open challenges.

引用

页码：24189 / 24208

页数：20

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