Benzylic C(sp 3 )-H fluorination

被引：2

作者：

Atkins, Alexander P. ^{[1
]}

Dean, Alice C. ^{[1
]}

Lennox, Alastair J. J. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, England

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 20卷

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

benzylic; C-H functionalization; fluorination; photoredox catalysis; C-H FLUORINATION; CHEMISTRY RESEARCH AREAS; ELECTROLYTIC FLUORINATIONS; ANODIC FLUORINATION; C(SP(3))-H BONDS; AMINO-ACIDS; LIGHT; FUNCTIONALIZATION; DIFLUORINATION; PERSPECTIVE;

D O I：

10.3762/bjoc.20.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective fluorination of C(sp 3 )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp 3 )-H fluorination, and several methods that are selective for benzylic C-H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C-H bonds.

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页码：1527 / 1547

页数：21

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