Dermatological toxicity associated with the use of gilteritinib in relapsed acute myeloid leukemia with FLT3 mutation: a case report

被引：0
|
作者：
Roldan, Alicia Martin [1 ]
Alarcon-Payer, Carolina [1 ]
Suarez, Maria Del Mar Sanchez [1 ]
Morales, Alberto Jimenez [1 ]
机构：
[1] Hosp Univ Virgen Nieves, Hosp Pharm Dept, Granada 18014, Spain
来源：
ANTI-CANCER DRUGS | 2024年 / 35卷 / 09期
关键词：
FLT3; mutation; gilteritinib; granuloma annulare; neutrophilic dermatosis; relapsed/refractory AML; CHEMOTHERAPY; THERAPY;
D O I：
10.1097/CAD.0000000000001634
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We present a case of a patient diagnosed with FLT3 mut+ acute myeloid leukemia with FLT3 and NMP1 mutations who did not respond to standard induction and consolidation treatment with chemotherapy. Due to the FLT3mut+ gene mutation and intermediate cytogenetic risk, treatment with gilteritinib is requested. After treatment she experienced a neutrophilic dermatosis and granuloma annulare that was resolved with gilteritinib dose reduction and specific treatment in coordination with the dermatology department.
引用
收藏
页码：872 / 874
页数：3
相关论文
共 50 条
  • [1] Gilteritinib use in the treatment of relapsed or refractory acute myeloid leukemia with a FLT3 mutation
    Ballesta-Lopez, Octavio
    Solana-Altabella, Antonio
    Megias-Vericat, Juan Eduardo
    Martinez-Cuadron, David
    Montesinos, Pau
    FUTURE ONCOLOGY, 2020, 17 (02) : 215 - 228
  • [2] Gilteritinib in the treatment of relapsed and refractory acute myeloid leukemia with a FLT3 mutation
    Chew, Serena
    Mackey, Melissa C.
    Jabbour, Elias
    THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 11
  • [3] Gilteritinib for the treatment of patients with FLT3 mutated relapsed or refractory acute myeloid leukemia
    Wang, Eunice S.
    EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT, 2019, 4 (03): : 105 - 112
  • [4] Gilteritinib: a novel FLT3 inhibitor for acute myeloid leukemia
    Zhao, Juanjuan
    Song, Yongping
    Liu, Delong
    BIOMARKER RESEARCH, 2019, 7 (01)
  • [5] Gilteritinib clinical activity in relapsed/refractory FLT3 mutated acute myeloid leukemia previously treated with FLT3 inhibitors
    Numan, Yazan
    Abdel Rahman, Zaid
    Grenet, Justin
    Boisclair, Stephanie
    Bewersdorf, Jan Philipp
    Collins, Cailin
    Barth, Dylan
    Fraga, Martina
    Bixby, Dale L.
    Zeidan, Amer M.
    Yilmaz, Musa
    Desai, Pankil
    Mannis, Gabriel
    Deutsch, Yehuda E.
    Abaza, Yasmin
    Dinner, Shira
    Frankfurt, Olga
    Litzow, Mark
    Al-Kali, Aref
    Foran, James M.
    Sproat, Lisa Z.
    Jovanovic, Borko
    Daver, Naval
    Perl, Alexander E.
    Altman, Jessica K.
    AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (03) : 322 - 328
  • [6] Case Report: A Novel Activating FLT3 Mutation in Acute Myeloid Leukemia
    Bruno, Samantha
    Bandini, Lorenza
    Patuelli, Agnese
    Robustelli, Valentina
    Venturi, Claudia
    Mancini, Manuela
    Forte, Dorian
    De Santis, Sara
    Monaldi, Cecilia
    Grassi, Alessandra
    Chiurumbolo, Gabriella
    Paolini, Stefania
    Cristiano, Gianluca
    Papayannidis, Cristina
    Sartor, Chiara
    Nanni, Jacopo
    Ottaviani, Emanuela
    Curti, Antonio
    Cavo, Michele
    Soverini, Simona
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [7] Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia
    Zhang, Yvyin
    Wang, Peihong
    Wang, Yang
    Shen, Yang
    BIOMARKER RESEARCH, 2023, 11 (01)
  • [8] Gilteritinib Reduces FLT3 Expression in Acute Myeloid Leukemia Cells
    Thai, Thi Lam
    Han, Sun-Young
    BIOMOLECULES & THERAPEUTICS, 2024, 32 (05) : 577 - 581
  • [9] Gilteritinib in Isolated Breast Relapse of FLT3 Positive Acute Myeloid Leukemia: A Case Report and Review of Literature
    Arrigo, Giulia
    D'Ardia, Stefano
    Audisio, Ernesta
    Cerrano, Marco
    Freilone, Roberto
    Giai, Valentina
    Secreto, Carolina
    Urbino, Irene
    Frairia, Chiara
    ACTA HAEMATOLOGICA, 2022, 145 (05) : 566 - 570
  • [10] Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia
    Daver, Naval
    Perl, Alexander E.
    Maly, Joseph
    Levis, Mark
    Ritchie, Ellen
    Litzow, Mark
    McCloskey, James
    Smith, Catherine C.
    Schiller, Gary
    Bradley, Terrence
    Tiu, Ramon, V
    Naqvi, Kiran
    Dail, Monique
    Brackman, Deanna
    Siddani, Satya
    Wang, Jing
    Chyla, Brenda
    Lee, Paul
    Altman, Jessica K.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (35) : 4048 - +
12345