Ligand-Boosted Copper Catalysis for Air-Tolerant Methoxylation of (Hetero)aryl Halides With Sodium Methoxide

被引：0

作者：

Xu, Ke ^{[1
]}

Wu, Shigang ^{[1
]}

Zou, Gang ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2024年 / 38卷 / 12期

关键词：

anisoles; aryl halides; bipyridine; copper catalysis; methoxylation; ARYL BROMIDES; PRACTICAL SYNTHESIS; COUPLING REACTIONS; ETHERS; MECHANISMS; IODIDES; MILD;

D O I：

10.1002/aoc.7708

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An air-tolerant, simple yet highly efficient copper-catalyzed methoxylation of (hetero)aryl bromides and some activated chlorides has been developed by using copper(II) chloride/2,2-bipyridine as catalyst precursor. A wide range of (hetero)aryl bromides and electron-deficient chlorides could be efficiently methoxylated in good to excellent yields at 1-mol% catalyst loading albeit showing a functional group compatibility dependent on the electronic properties of aryl ring. Applications of the practical protocol have been demonstrated in multigram synthesis of 3,4,5-trimethoxytoluene.

引用

页数：9

共 38 条

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