Diversely Functionalized Pyridine Ring-fused Heterocycles and their Anticancer Properties

被引：1

作者：

Narasimhamurthy, Kereyagalahally H. ^{[1
]}

Girish, Yarabahally R. ^{[2
]}

Swaroop, Toreshettahally R. ^{[1
]}

Rangappa, Kanchugarakoppal S. ^{[3
]}

机构：

[1] Univ Mysore, Dept Studies Organ Chem, Mysuru 570006, Karnataka, India

[2] Adichunchanagiri Univ, Ctr Res & Innovat, Sch Nat Sci, BGSIT, Mandya 571448, Karnataka, India

[3] Univ Mysore, Inst Excellence, Mysuru 570006, Karnataka, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2024年 / 21卷 / 11期

关键词：

Leukemia; anticancer; pyridine; pyridine conjugated; heterocycles; nitrogen containing heterocycles; BIOLOGICAL EVALUATION; POTENTIAL ANTICANCER; TUBULIN POLYMERIZATION; ANTITUMOR-ACTIVITY; DERIVATIVES; DESIGN; ANALOGS; AGENTS; INHIBITORS;

D O I：

10.2174/1570180820666230516111340

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Among N-containing heterocycles, pyridine occupies a prominent position due to its presence in nature. Many enzymes in living systems, which are involved in redox reactions, contain pyridine moiety. In addition, its importance in medicinal chemistry and its presence in drugs are well documented. Several pyridine containing compounds are well-known as tubulin polymerization inhibitors and are found to bind with androgen receptors, kinases, carbonic anhydrase and topoisomerase. In recent years, researching have been modifying pyridine containing entities to treat cancer. This review sheds light on recent developments in anticancer studies of pyridine ring-fused heterocyclic compounds.

引用

页码：1904 / 1912

页数：9

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