One-pot synthesis of 3,4-dihydro-[1,3]oxazin-2-ones by BF3 Et2O-mediated approach of N-Boc phenylsulfonyl with ynamides

被引：0
|
作者：
Wang, Rui-An [1 ]
Ren, Li-Zheng [1 ]
Han, Shi-Qing [1 ]
Wei, Bang-Guo [2 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhu South Rd, Nanjing 211816, Peoples R China
[2] Fudan Univ, Sch Pharm, Dept Nat Med, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON LETTERS | 2024年 / 147卷
关键词：
3,4-Dihydro-[1,3]oxazin-2-ones; BF3 & sdot; Et2O-mediated; N-Boc phenylsulfonyl; Ynamides; EFAVIRENZ;
D O I：
10.1016/j.tetlet.2024.155222
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot approach to access functionalized 3,4-dihydro-[1,3]oxazin-2-one skeletons has been developed through BF3Et2O-mediated 3 Et 2 O-mediated addition-cyclization of ynamides and N- Boc phenylsulfones. The metal- free catalytic method exhibits good functional group compatibility. This study provides a practical new method for the synthesis of oxazinone skeletons.
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页数：5
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