Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment

被引：2
作者：
Ma, Qianquan [1 ]
Li, Haoyu [2 ,3 ,8 ]
Song, Zhihao [2 ,3 ,8 ]
Deng, Zhili [4 ,5 ,6 ]
Huang, Wei [2 ,3 ,7 ,8 ]
Liu, Qing [2 ,3 ,8 ]
机构：
[1] Peking Univ, Peking Univ Third Hosp, Dept Neurosurg, Beijing, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Hunan Key Lab Aging Biol, Changsha, Peoples R China
[6] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[7] Cent South Univ, Xiangya Hosp, Res Ctr Carcinogenesis & Targeted Therapy, Changsha, Peoples R China
[8] Clin Res Ctr Skull Base Surg & Neurooncol Hunan Pr, Changsha, Peoples R China
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2024年 / 161卷
基金：
中国国家自然科学基金;
关键词：
BCAA; Metabolism; Cancer development; Cancer immunology; Cancer microenvironment; PROMOTES CELL-PROLIFERATION; BCAA CATABOLISM; GENE-EXPRESSION; METABOLISM; DISEASE; PROGRESSION; TRANSPORT; MTOR; SUPPLEMENTATION; LEUKEMOGENESIS;
D O I：
10.1016/j.metabol.2024.156016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Metabolism of Branched-chain amino acids (BCAAs) is essential for the nutrient necessities in mammals. Catalytic enzymes serve to direct the whole-body BCAAs oxidation which involve in the development of various metabolic disorders. The reprogrammed metabolic elements are also responsible for malignant oncogenic processes, and favor the formation of distinctive immunosuppressive microenvironment surrounding different cancers. The impotent immune surveillance related to BCAAs dysfunction is a novel topic to investigate. Here we focus on the BCAA catalysts that contribute to metabolic changes and dysregulated immune reactions in cancer progression. We summarize the current knowledge of BCAA catalyzation, highlighting the interesting roles of BCAA metabolism in the treatment of cancers.
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页数：15
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共 167 条
[1]  
Aktar Nasrin, 2022, J Oncol, V2022, P8901326, DOI 10.1155/2022/8901326
[2]   A single nucleotide polymorphism in BCAT1 gene is associated with type 2 diabetes mellitus [J].
Alfaqih, Mahmoud A. ;
Abu-Khdair, Zaina E. ;
Khabour, Omar ;
Kheirallah, Khalid A. ;
Khanfar, Mariam .
ACTA BIOCHIMICA POLONICA, 2022, 69 (01) :19-24
[3]   Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+ T Cells [J].
Ananieva, Elitsa A. ;
Patel, Chirag H. ;
Drake, Charles H. ;
Powell, Jonathan D. ;
Hutson, Susan M. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (27) :18793-18804
[4]   Transcriptional hallmarks of cancer cell lines reveal an emerging role of branched chain amino acid catabolism [J].
Antanaviciute, Ieva ;
Mikalayeva, Valeryia ;
Cesleviciene, Ieva ;
Milasiute, Gintare ;
Skeberdis, Vytenis Arvydas ;
Bordel, Sergio .
SCIENTIFIC REPORTS, 2017, 7
[5]   Branched-chain amino acid supplementation and the immune response of long-distance athletes [J].
Bassit, RA ;
Sawada, LA ;
Bacurau, RFP ;
Navarro, F ;
Martins, E ;
Santos, RVT ;
Caperuto, EC ;
Rogeri, P ;
Rosa, LFBP .
NUTRITION, 2002, 18 (05) :376-379
[6]   IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy [J].
Beziaud, Laurent ;
Young, C. Megan ;
Alonso, Angela Madurga ;
Norkin, Maxim ;
Minafra, Anna Rita ;
Huelsken, Joerg .
CELL STEM CELL, 2023, 30 (06) :818-+
[7]   Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity [J].
Biswas, Dipsikha ;
Slade, Logan ;
Duffley, Luke ;
Mueller, Neil ;
Dao, Khoi Thien ;
Mercer, Angella ;
El Hiani, Yassine ;
Kienesberger, Petra ;
Pulinilkunnil, Thomas .
CELL DEATH DISCOVERY, 2021, 7 (01)
[8]   Whole-body metabolic fate of branched-chain amino acids [J].
Blair, Megan C. ;
Neinast, Michael D. ;
Arany, Zoltan .
BIOCHEMICAL JOURNAL, 2021, 478 (04) :765-776
[9]   Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase [J].
Caballero, Julio ;
Vergara-Jaque, Ariela ;
Fernandez, Michael ;
Coll, Deysma .
MOLECULAR DIVERSITY, 2009, 13 (04) :493-500
[10]   BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti-PD-1/PD-L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity [J].
Cai, Zhiyong ;
Chen, Jinbo ;
Yu, Zhengzheng ;
Li, Huihuang ;
Liu, Zhi ;
Deng, Dingshan ;
Liu, Jinhui ;
Chen, Chunliang ;
Zhang, Chunyu ;
Ou, Zhenyu ;
Chen, Minfeng ;
Hu, Jiao ;
Zu, Xiongbing .
ADVANCED SCIENCE, 2023, 10 (08)
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