Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer

被引:6
|
作者
da Silva, Ines V. [1 ,2 ]
Mlinaric, Monika [3 ]
Lourenco, Ana Rita [1 ,2 ]
Perez-Garcia, Olivia [1 ,2 ]
Gasparovic, Ana Cipak [3 ]
Soveral, Graca [1 ,2 ]
机构
[1] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, P-1649003 Lisbon, Portugal
[2] Univ Lisbon, Fac Pharm, Dept Pharmaceut Sci & Med, P-1649003 Lisbon, Portugal
[3] Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia
关键词
aquaporin; hydrogen peroxide; membrane transport; redox signaling; HYDROGEN-PEROXIDE TRANSPORT; CELL-MIGRATION; AQUAPORIN; 3; DIFFERENTIAL EXPRESSION; MEMBRANE-TRANSPORT; NADPH OXIDASES; WATER; CHANNEL; PROLIFERATION; PERMEABILITY;
D O I
10.3390/ijms25158381
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins have the unique capability to transport hydrogen peroxide (H2O2), a reactive oxygen species involved in various cellular signaling pathways and regulation of oxidative stress responses. The regulation of H2O2 levels is crucial for maintaining cellular homeostasis, and peroxiporins play a significant role in this process by modulating its intracellular and extracellular concentrations. This ability to facilitate the passage of H2O2 positions peroxiporins as key players in redox biology and cellular signaling, with implications for understanding and treating various diseases linked to oxidative stress and inflammation. This review provides updated information on the physiological roles of peroxiporins and their implications in disease, emphasizing their potential as novel biomarkers and drug targets in conditions where they are dysregulated, such as inflammation and cancer.
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页数:18
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