The N-(Benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)amino)butanamide

被引：0
|
作者：
Pilotzi-Xahuentitla, Hugo [1 ]
Canche-Naal, Gabriela del Carmen [2 ]
Ortiz-Andrade, Rolffy Ruben [2 ]
Navarrete-Vazquez, Gabriel [3 ]
Hernandez-Nunez, Emanuel [4 ]
机构：
[1] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Recursos Mar, Merida 97310, Yucatan, Mexico
[2] Univ Autonoma Yucatan, Fac Quim, Lab Farmacol, Merida 97069, Yucatan, Mexico
[3] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca 62209, Morelos, Mexico
[4] Inst Tecnol Super Calkini, Dept Posgrad Invest, Av Ah Canul S-N Carretera Fed, Campeche 24930, Mexico
来源：
MOLBANK | 2024年 / 2024卷 / 03期
关键词：
benzothiazole; benzoxazole; antidiabetic; molecular docking; EFFICIENT;
D O I：
10.3390/M1854
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained at a 76% global yield using accessible starting materials and a methodology in two reaction steps. Furthermore, we conducted docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent.
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页数：6
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