SARS-CoV-2 Seropositivity in Nursing Home Staff and Residents during the First SARS-CoV-2 Wave in Flanders, Belgium

被引：0

作者：

De Rop, Liselore ^{[1
]}

Vercruysse, Hanne ^{[2
]}

Alenus, Ulysse ^{[3
]}

Brusselmans, Judith ^{[3
,4
]}

Callens, Steven ^{[5
]}

Claeys, Maud ^{[3
]}

De Coene, Nimphe ^{[6
]}

Persyn, Peter ^{[7
]}

Padalko, Elizaveta ^{[8
,9
]}

Heytens, Stefan ^{[6
]}

Verbakel, Jan Y. ^{[1
]}

Cools, Piet ^{[3
]}

机构：

[1] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, LUHTAR, B-3000 Leuven, Belgium

[2] Liantis Occupat Hlth Serv, Res & Analyt, B-8000 Brugge, Belgium

[3] Univ Ghent, Fac Med & Hlth Sci, Dept Diag Sci, B-9000 Ghent, Belgium

[4] Univ Ghent, Fac Med & Hlth Sci, Dept Human Struct & Repair, B-9000 Ghent, Belgium

[5] Ghent Univ Hosp, Dept Internal Med & Infect Dis, B-9000 Ghent, Belgium

[6] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, B-9000 Ghent, Belgium

[7] Korian Belgium NH, Med Dept, B-2550 Kontich, Belgium

[8] Univ Hosp Ghent, Lab Clin Biol, B-9000 Ghent, Belgium

[9] Univ Ghent, Dept Diag Sci, B-9000 Ghent, Belgium

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 09期

关键词：

nursing homes; COVID-19; SARS-CoV-2; seroprevalence; RT-PCR testing; reinfection; REINFECTION; INFECTION; COVID-19;

D O I：

10.3390/v16091461

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

(1) Background: early in the COVID-19 pandemic, reverse transcription polymerase chain reaction (RT-PCR) testing was limited. Assessing seroprevalence helps understand prevalence and reinfection risk. However, such data are lacking for the first epidemic wave in Belgian nursing homes. Therefore, we assessed SARS-CoV-2 seroprevalence and cumulative RT-PCR positivity in Belgian nursing homes and evaluated reinfection risk. (2) Methods: we performed a cross-sectional study in nine nursing homes in April and May 2020. Odds ratios (ORs) were calculated to compare the odds of (re)infection between seropositive and seronegative participants. (3) Results: seroprevalence was 21% (95% CI: 18-23): 22% (95% CI: 18-25) in residents and 20% (95% CI: 17-24) in staff. By 20 May 2020, cumulative RT-PCR positivity was 16% (95% CI: 13-21) in residents and 8% (95% CI: 6-12) in staff. ORs for (re)infection in seropositive (compared to seronegative) residents and staff were 0.22 (95% CI: 0.06-0.72) and 3.15 (95% CI: 1.56-6.63), respectively. (4) Conclusion: during the first wave, RT-PCR test programmes underestimated the number of COVID-19 cases. The reinfection rate in residents was 3%, indicating protection, while it was 21% in staff, potentially due to less cautious health behaviour. Future outbreaks should use both RT-PCR and serological testing for complementary insights into transmission dynamics.

引用

页数：13

共 39 条

[21] High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19: Prospective cohort study, England [J].

Ladhani, Shamez N. ;

Jeffery-Smith, Anna ;

Patel, Monika ;

Janarthanan, Roshni ;

Fok, Jonathan ;

Crawley-Boevey, Emma ;

Vusirikala, Amoolya ;

De Olano, Elena Fernandez Ruiz ;

Perez, Marina Sanchez ;

Tang, Suzanne ;

Dun-Campbell, Kate ;

Wynne-Evans, Edward ;

Bell, Anita ;

Patel, Bharat ;

Amin-Chowdhury, Zahin ;

Aiano, Felicity ;

Paranthaman, Karthik ;

Ma, Thomas ;

Saavedra-Campos, Maria ;

Ellis, Joanna ;

Chand, Meera ;

Brown, Kevin ;

Ramsay, Mary E. ;

Hopkins, Susan ;

Shetty, Nandini ;

Chow, J. Yimmy ;

Gopal, Robin ;

Zambon, Maria .

ECLINICALMEDICINE, 2020, 28

[22] Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers [J].

Lumley, S. F. ;

O'Donnell, D. ;

Stoesser, N. E. ;

Matthews, P. C. ;

Howarth, A. ;

Hatch, S. B. ;

Marsden, B. D. ;

Cox, S. ;

James, T. ;

Warren, F. ;

Peck, L. J. ;

Ritter, T. G. ;

de Toledo, Z. ;

Warren, L. ;

Axten, D. ;

Cornall, R. J. ;

Jones, E. Y. ;

Stuart, D. I. ;

Screaton, G. ;

Ebner, D. ;

Hoosdally, S. ;

Chand, M. ;

Crook, D. W. ;

O'Donnell, A. -M. ;

Conlon, C. P. ;

Pouwels, K. B. ;

Walker, A. S. ;

Peto, T. E. A. ;

Hopkins, S. ;

Walker, T. M. ;

Jeffery, K. ;

Eyre, D. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (06) :533-540

[23] Temporal Associations between Community Incidence of COVID-19 and Nursing Home Outbreaks in Ontario, Canada [J].

Malikov, Kamil ;

Huang, Qing ;

Shi, Shengli ;

Stall, Nathan M. ;

Tuite, Ashleigh R. ;

Hillmer, Michael P. .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2021, 22 (02) :260-262

[24] At what times during infection is SARS-CoV-2 detectable and no longer detectable using RT-PCR-based tests? A systematic review of individual participant data [J].

Mallett, Sue ;

Allen, A. Joy ;

Graziadio, Sara ;

Taylor, Stuart A. ;

Sakai, Naomi S. ;

Green, Kile ;

Suklan, Jana ;

Hyde, Chris ;

Shinkins, Bethany ;

Zhelev, Zhivko ;

Peters, Jaime ;

Turner, Philip J. ;

Roberts, Nia W. ;

di Ruffano, Lavinia Ferrante ;

Wolff, Robert ;

Whiting, Penny ;

Winter, Amanda ;

Bhatnagar, Gauraang ;

Nicholson, Brian D. ;

Halligan, Steve .

BMC MEDICINE, 2020, 18 (01)

[25] Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington [J].

McMichael, Temet M. ;

Currie, Dustin W. ;

Clark, Shauna ;

Pogosjans, Sargis ;

Kay, Meagan ;

Schwartz, Noah G. ;

Lewis, James ;

Baer, Atar ;

Kawakami, Vance ;

Lukoff, Margaret D. ;

Ferro, Jessica ;

Brostrom-Smith, Claire ;

Rea, Thomas D. ;

Sayre, Michael R. ;

Riedo, Francis X. ;

Russell, Denny ;

Hiatt, Brian ;

Montgomery, Patricia ;

Rao, Agam K. ;

Chow, Eric J. ;

Tobolowsky, Farrell ;

Hughes, Michael J. ;

Bardossy, Ana C. ;

Oakley, Lisa P. ;

Jacobs, Jesica R. ;

Stone, Nimalie D. ;

Reddy, Sujan C. ;

Jernigan, John A. ;

Honein, Margaret A. ;

Clark, Thomas A. ;

Duchin, Jeffrey S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (21) :2005-2011

[26] Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study [J].

Mortgat, Laure ;

Verdonck, Kristien ;

Hutse, Veronik ;

Thomas, Isabelle ;

Barbezange, Cyril ;

Heyndrickx, Leo ;

Fischer, Natalie ;

Vuylsteke, Bea ;

Kabouche, Ines ;

Arien, Kevin K. ;

Desombere, Isabelle ;

Duysburgh, Els .

BMJ OPEN, 2021, 11 (06)

[27] Seroprevalence Survey of Anti-SARS-CoV-2 Antibodies in a Population of Emilia-Romagna Region, Northern Italy [J].

Paduano, Stefania ;

Galante, Pasquale ;

Berselli, Nausicaa ;

Ugolotti, Luca ;

Modenese, Alberto ;

Poggi, Alessandro ;

Malavolti, Marcella ;

Turchi, Sara ;

Marchesi, Isabella ;

Vivoli, Roberto ;

Perlini, Paola ;

Bellucci, Rossana ;

Gobba, Fabriziomaria ;

Vinceti, Marco ;

Filippini, Tommaso ;

Bargellini, Annalisa .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2022, 19 (13)

[28]

Peeters I., 2021, Report No.: D/2021/14.440/57

[29] Why is it difficult to accurately predict the COVID-19 epidemic? [J].

Roda, Weston C. ;

Varughese, Marie B. ;

Han, Donglin ;

Li, Michael Y. .

INFECTIOUS DISEASE MODELLING, 2020, 5 :271-281

[30]

Sciensano, Aantal Bloeddonoren en Gezondheidswerkers met Antistoffen Tegen Coronavirus Blijft Stabiel Internet

← 1 2 3 4 →