SARS-CoV-2 Seropositivity in Nursing Home Staff and Residents during the First SARS-CoV-2 Wave in Flanders, Belgium

被引：0

作者：

De Rop, Liselore ^{[1
]}

Vercruysse, Hanne ^{[2
]}

Alenus, Ulysse ^{[3
]}

Brusselmans, Judith ^{[3
,4
]}

Callens, Steven ^{[5
]}

Claeys, Maud ^{[3
]}

De Coene, Nimphe ^{[6
]}

Persyn, Peter ^{[7
]}

Padalko, Elizaveta ^{[8
,9
]}

Heytens, Stefan ^{[6
]}

Verbakel, Jan Y. ^{[1
]}

Cools, Piet ^{[3
]}

机构：

[1] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, LUHTAR, B-3000 Leuven, Belgium

[2] Liantis Occupat Hlth Serv, Res & Analyt, B-8000 Brugge, Belgium

[3] Univ Ghent, Fac Med & Hlth Sci, Dept Diag Sci, B-9000 Ghent, Belgium

[4] Univ Ghent, Fac Med & Hlth Sci, Dept Human Struct & Repair, B-9000 Ghent, Belgium

[5] Ghent Univ Hosp, Dept Internal Med & Infect Dis, B-9000 Ghent, Belgium

[6] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, B-9000 Ghent, Belgium

[7] Korian Belgium NH, Med Dept, B-2550 Kontich, Belgium

[8] Univ Hosp Ghent, Lab Clin Biol, B-9000 Ghent, Belgium

[9] Univ Ghent, Dept Diag Sci, B-9000 Ghent, Belgium

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 09期

关键词：

nursing homes; COVID-19; SARS-CoV-2; seroprevalence; RT-PCR testing; reinfection; REINFECTION; INFECTION; COVID-19;

D O I：

10.3390/v16091461

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

(1) Background: early in the COVID-19 pandemic, reverse transcription polymerase chain reaction (RT-PCR) testing was limited. Assessing seroprevalence helps understand prevalence and reinfection risk. However, such data are lacking for the first epidemic wave in Belgian nursing homes. Therefore, we assessed SARS-CoV-2 seroprevalence and cumulative RT-PCR positivity in Belgian nursing homes and evaluated reinfection risk. (2) Methods: we performed a cross-sectional study in nine nursing homes in April and May 2020. Odds ratios (ORs) were calculated to compare the odds of (re)infection between seropositive and seronegative participants. (3) Results: seroprevalence was 21% (95% CI: 18-23): 22% (95% CI: 18-25) in residents and 20% (95% CI: 17-24) in staff. By 20 May 2020, cumulative RT-PCR positivity was 16% (95% CI: 13-21) in residents and 8% (95% CI: 6-12) in staff. ORs for (re)infection in seropositive (compared to seronegative) residents and staff were 0.22 (95% CI: 0.06-0.72) and 3.15 (95% CI: 1.56-6.63), respectively. (4) Conclusion: during the first wave, RT-PCR test programmes underestimated the number of COVID-19 cases. The reinfection rate in residents was 3%, indicating protection, while it was 21% in staff, potentially due to less cautious health behaviour. Future outbreaks should use both RT-PCR and serological testing for complementary insights into transmission dynamics.

引用

页数：13

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