Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus

被引：0
|
作者：
Yao, Dan [1 ]
Shen, Cai [2 ]
Zhang, Xinghe [2 ]
Tang, Jiayue [1 ]
Yu, Jingwen [1 ]
Tu, Maolin [1 ]
Panpipat, Worawan [3 ]
Chaijan, Manat [3 ]
Zhang, Hong [4 ]
Xu, Xuebing [4 ]
Liu, Yanan [1 ]
Cheong, Ling-Zhi [2 ]
机构：
[1] Ningbo Univ, Coll Food Sci & Engn, Zhejiang Malaysia Joint Res Lab Agr Prod Proc & Nu, Key Lab Anim Prot Food Deep Proc Technol Zhejiang, Ningbo 315800, Zhejiang, Peoples R China
[2] Univ Melbourne, Fac Vet & Agr Sci, Sch Agr & Food, Melbourne 3010, Australia
[3] Walailak Univ, Sch Agr Technol & Food Ind, Nakhon Si Thammarat 80161, Thailand
[4] Wilmar Shanghai Biotechnol Res & Dev Ctr Co Ltd, 118 Gaodong Rd, Shanghai 200137, Peoples R China
来源：
FOOD CHEMISTRY | 2024年 / 460卷
关键词：
Gestational diabetes mellitus; Mature human Milk; Mass spectrometry-based metabolomics; Bioinformatic analysis; Linoleic acid metabolism disorder; LIPOKINE 12,13-DIHOME; METABOLISM; GROWTH;
D O I：
10.1016/j.foodchem.2024.140663
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid ChromatographyMass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.
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页数：10
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