The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease

被引：8

作者：

Hu, Junhui ^{[1
]}

Huang, Baiqing ^{[2
]}

Chen, Kang ^{[3
]}

机构：

[1] West Anhui Univ, Sch Phys Educ, Luan, Peoples R China

[2] Yunnan Minzu Univ, Sch Phys Educ, Kunming, Peoples R China

[3] Tianjin Univ Sport, Tianjin Key Lab Exercise Physiol & Sports Med, Tianjin, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2024年 / 16卷

关键词：

Alzheimer's disease; physical exercise; neuroinflammation; microglial activation; blood-brain barrier integrity; MOUSE MODEL; RAT MODEL; BDNF; NEUROGENESIS; INFLAMMATION; IMPAIRMENT; ASTROCYTES; CELLS; MICE; TAU;

D O I：

10.3389/fnagi.2024.1444716

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction: Alzheimer's disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy of physical exercise as a non-pharmacological intervention to mitigate the impacts of AD. Methods: This review draws on recent studies that investigate the effects of physical exercise on neuroinflammation and neuronal enhancement in individuals with AD. Results: Consistent physical exercise alters neuroinflammatory pathways, enhances cognitive functions, and bolsters brain health among AD patients. It favorably influences the activation states of microglia and astrocytes, fortifies the integrity of the blood-brain barrier, and attenuates gut inflammation associated with AD. These changes are associated with substantial improvements in cognitive performance and brain health indicators. Discussion: The findings underscore the potential of integrating physical exercise into comprehensive AD management strategies. Emphasizing the necessity for further research, this review advocates for the refinement of exercise regimens to maximize their enduring benefits in decelerating the progression of AD.

引用

页数：15

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