Does flaxseed supplementation affect apo-lipoproteins? A GRADE-assessed systematic review and meta-analysis

被引：2

作者：

Benam, Sasan Pourbagher ^{[1
]}

Mirabdali, Seyedsaber ^{[2
]}

Ebrahimi, Negar ^{[3
]}

Daneshvar, Maziar ^{[4
]}

Vahedi, Shima ^{[5
]}

Abbasifard, Fateme ^{[6
]}

Rounagh, Mahsa ^{[7
]}

机构：

[1] Urmia Univ Med Sci, Fac Med, Orumiyeh, Iran

[2] Kermanshah Univ Med Sci, Kermanshah, Iran

[3] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[4] Univ Tehran Med Sci, Tehran, Iran

[5] Kaunas Univ Technol, Fac Chem Technol, Dept Food Sci & Technol, Kaunas, Lithuania

[6] Islamic Azad Univ, Sch Med, Tonekabon Branch, Mazandaran, Iran

[7] Islamic Azad Univ, Sci & Res Branch Med Sci, Tehran, Iran

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2024年 / 174卷

关键词：

Flaxseed; Lipoproteins; Meta-analysis; Systematic review; DOUBLE-BLIND; LDL-CHOLESTEROL; HEART-DISEASE; SERUM-LIPIDS; MANAGEMENT; APOLIPOPROTEINS; WOMEN; RISK; ACID; EXPRESSION;

D O I：

10.1016/j.prostaglandins.2024.106872

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies indicated the ameliorating effects of flaxseed supplementation on apolipoproteins, although others have conflicting results. Therefore, the present research was conducted in order to accurately and definitively understand the effect of flaxseed on apolipoproteins in adults. All articles published up to Juan 2024 were systematically searched through PubMed, Scopus, Embase, and Web of Science to collect all randomized clinical trials (RCTs). A random effects model was used to measure the combined effect sizes. Also, standardized mean difference (SMD) and 95 % confidence interval (CI) were used to report the combined effect size. Our results showed that flaxseed supplementation significantly reduced apo-BI (SMD: -0.57; 95 % CI: -0.95, -0.19, p = 0.003; I-2 = 83.2 %, heterogeneity p < 0.001) and lipo(a) decreased (SMD: -0.34; 95 % CI: -0.59, -0.09, p=0.007; I-2=30.3 %, heterogeneity p=0.197). However, flaxseed did not change apo-AI levels (SMD: -0.37; 95 % CI: -0.87, 0.13, p = 0.146; I-2 = 89.2 %, p-heterogeneity < 0.001). This meta-analysis has shown that flaxseed supplementation may have beneficial effects on apolipoproteins. Future high-quality, long-term clinical trials are needed to confirm our results.

引用

页数：10

共 59 条

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