Adipose-derived stem cell therapy for spinal cord injuries: Advances, challenges, and future directions

被引：1

作者：

Shimizu, Yusuke ^{[1
]}

Ntege, Edward Hosea ^{[1
]}

Takahara, Eisaku ^{[1
]}

Matsuura, Naoki ^{[1
]}

Matsuura, Rikako ^{[1
]}

Kamizato, Kota ^{[2
]}

Inoue, Yoshikazu ^{[3
]}

Sowa, Yoshihiro ^{[4
]}

Sunami, Hiroshi ^{[5
]}

机构：

[1] Univ Ryukyus, Grad Sch Med, Dept Plast & Reconstruct Surg, 207 Uehara, Nakagami, Okinawa 9030215, Japan

[2] Univ Ryukyus, Grad Sch Med, Dept Anesthesiol, 207 Uehara, Nishihara, Okinawa 9030215, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Plast & Reconstruct Surg, 1-98 Dengakugakubo, Toyoake, Aichi 4701192, Japan

[4] Jichi Med Univ, Dept Plast Surg, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan

[5] Univ Ryukyus, Sch Med, Ctr Adv Med Res, 207 Uehara, Nakagami, Okinawa 9030215, Japan

来源：

REGENERATIVE THERAPY | 2024年 / 26卷

基金：

日本学术振兴会;

关键词：

Spinal cord injury; Adipose-derived stem cells; Cell therapy; Neuroregeneration; Paralysis; Functional recovery; IMPROVES FUNCTIONAL RECOVERY; SENSORIMOTOR RECOVERY; INTRAVENOUS-INFUSION; SCHWANN-CELLS; BONE-MARROW; TRANSPLANTATION; REGENERATION; PROMOTES; MODEL; DIFFERENTIATION;

D O I：

10.1016/j.reth.2024.07.007

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Spinal cord injury (SCI) has limited treatment options for regaining function. Adipose-derived stem cells (ADSCs) show promise owing to their ability to differentiate into multiple cell types, promote nerve cell survival, and modulate inflammation. This review explores ADSC therapy for SCI, focusing on its potential for improving function, preclinical and early clinical trial progress, challenges, and future directions. Preclinical studies have demonstrated ADSC transplantation's effectiveness in promoting functional recovery, reducing cavity formation, and enhancing nerve regrowth and myelin repair. To improve ADSC efficacy, strategies including genetic modification and combination with rehabilitation are being explored. Early clinical trials have shown safety and feasibility, with some suggesting motor and sensory function improvements. Challenges remain for clinical translation, including optimizing cell survival and delivery, determining dosing, addressing tumor formation risks, and establishing standardized protocols. Future research should focus on overcoming these challenges and exploring the potential for combining ADSC therapy with other treatments, including rehabilitation and medication. (c) 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/lice nses/by-nc-nd/4.0/).

引用

页码：508 / 519

页数：12

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