Innovative strategies in metal-organic frameworks for enhanced electrochemiluminescence biosensors

Electrochemiluminescence (ECL) is a technique that integrates the benefits of both chemiluminescence and electrochemistry. Early illness diagnosis and hazardous material detection have both benefited greatly from its benefits, which include minimal background signal, high sensitivity, and easy operation. A novel class of porous materials known as metal-organic frameworks (MOFs) is created when organic ligands and inorganic metal nodes self-assemble. Its enormous specific surface area, many functionalized sites, adaptable structure, and range of applications in biomedicine, biosensing, and other domains have made it a hot topic in chemical and biological research. This article examines the development of MOF applications in recent years pertaining to the production of electrochemiluminescence biosensors. First, the effects of metal ions on aggregation induced electrochemiluminescence are analyzed, and design approaches for meeting the needs of ECL applications are discussed. The applications of MOFs are then categorized and described based on three factors: electroactivity, catalytically active chemicals, and carriers, in accordance with the many roles of MOFs in ECL. Lastly, present problems and obstacles are examined, and potential future routes for growth are suggested.