The Janus kinase/signal transducers and activators of transcription (JAK/ STAT) pathway contributes to the defense against bacterial infection in the pea aphid

被引：1
作者：
Zhao, Yu-Jie [1 ]
Li, Yue-Ming [1 ]
Yang, Ting [1 ]
Lu, Zhiqiang [1 ]
机构：
[1] Northwest A&F Univ, Coll Plant Protect, State Key Lab Crop Stress Resistance & High Effici, Yangling 712100, Shaanxi, Peoples R China
来源：
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 2024年 / 202卷
关键词：
JAK/STAT; Acyrthosiphon pisum; Defense; Bacterial infection; RNA interference; ANTIVIRAL IMMUNITY; SIGNALING PATHWAY; PATHOGEN;
D O I：
10.1016/j.pestbp.2024.105915
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is activated by infections of bacteria, fungi, viruses and parasites and mediated cellular and humoral immune responses. In the pea aphid Acyrthosiphon pisum little is known about the function of JAK/STAT signaling in its immune system. In this study, we first showed that expression of genes in the JAK/STAT signaling, including the receptors Domeless1/2, Janus kinase (JAK) and transcriptional factor Stat92E, is up-regulated upon bacteria Escherichia coli and Staphylococcus aureus and fungus Beauveria bassiana infections. After knockdown of expression of these genes by means of dsRNA injection, the aphids harbored more bacteria and suffered more death after infected with E. coli and S. aureus, but showed no significant change after B. bassiana infection. Our study suggests the JAK/STAT signaling contributes to the defense against bacterial infection in the pea aphid.
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页数：7
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  • [1] The JAK-STAT Pathway Controls Plasmodium vivax Load in Early Stages of Anopheles aquasalis Infection
    Bahia, Ana C.
    Kubota, Marina S.
    Tempone, Antonio J.
    Araujo, Helena R. C.
    Guedes, Bruno A. M.
    Orfano, Alessandra S.
    Tadei, Wanderli P.
    RioOs-Velasquez, Claudia M.
    Han, Yeon S.
    Secundino, Nagila F. C.
    Barillas-Mury, Carolina
    Pimenta, Paulo F. P.
    Traub-Csekoe, Yara M.
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (11):
  • [2] Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection
    Barillas-Mury, C
    Han, YS
    Seeley, D
    Kafatos, FC
    [J]. EMBO JOURNAL, 1999, 18 (04) : 959 - 967
  • [3] The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila
    Dostert, C
    Jouanguy, E
    Irving, P
    Troxler, L
    Galiana-Arnoux, D
    Hetru, C
    Hoffmann, JA
    Imler, JL
    [J]. NATURE IMMUNOLOGY, 2005, 6 (09) : 946 - 953
  • [4] Target antifungal peptides of immune signalling pathways in silkworm, Bombyx mori, against Beauveria bassiana
    Geng, T.
    Lu, F.
    Wu, H.
    Lou, D.
    Tu, N.
    Zhu, F.
    Wang, S.
    [J]. INSECT MOLECULAR BIOLOGY, 2021, 30 (01) : 102 - 112
  • [5] JAK/STAT signaling pathway-mediated immune response in silkworm (Bombyx mori) challenged by Beauveria bassiana
    Geng, Tao
    Lv, Ding-Ding
    Huang, Yu-Xia
    Hou, Cheng-Xiang
    Qin, Guang-Xing
    Guo, Xi-Jie
    [J]. GENE, 2016, 595 (01) : 69 - 76
  • [6] Immunity and other defenses in pea aphids, Acyrthosiphon pisum
    Gerardo, Nicole M.
    Altincicek, Boran
    Anselme, Caroline
    Atamian, Hagop
    Barribeau, Seth M.
    De Vos, Martin
    Duncan, Elizabeth J.
    Evans, Jay D.
    Gabaldon, Toni
    Ghanim, Murad
    Heddi, Adelaziz
    Kaloshian, Isgouhi
    Latorre, Amparo
    Moya, Andres
    Nakabachi, Atsushi
    Parker, Benjamin J.
    Perez-Brocal, Vincente
    Pignatelli, Miguel
    Rahbe, Yvan
    Ramsey, John S.
    Spragg, Chelsea J.
    Tamames, Javier
    Tamarit, Daniel
    Tamborindeguy, Cecilia
    Vincent-Monegat, Caroline
    Vilcinskas, Andreas
    [J]. GENOME BIOLOGY, 2010, 11 (02):
  • [7] Cooperative Regulation of the Induction of the Novel Antibacterial Listericin by Peptidoglycan Recognition Protein LE and the JAK-STAT Pathway
    Goto, Akira
    Yano, Tamaki
    Terashima, Jun
    Iwashita, Shinzo
    Oshima, Yoshiteru
    Kurata, Shoichiro
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (21) : 15731 - 15738
  • [8] The JAK/STAT Pathway
    Harrison, Douglas A.
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2012, 4 (03):
  • [9] Aphid facultative symbionts confer no protection against the fungal entomopathogen Batkoa apiculata
    Inchauregui, Rose
    Tallapragada, Keertana
    Parker, Benjamin
    [J]. PLOS ONE, 2023, 18 (05):
  • [10] Two atypical gram-negative bacteria-binding proteins are involved in the antibacterial response in the pea aphid (Acyrthosiphon pisum)
    Ji, J.
    Zhou, L.
    Xu, Z.
    Ma, L.
    Lu, Z.
    [J]. INSECT MOLECULAR BIOLOGY, 2021, 30 (04) : 427 - 435
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