Three possible diagnostic biomarkers for gastric cancer: miR-362-3p, miR-362-5p and miR-363-5p

被引：1
|
作者：
Aydinlou, Zahra Hassanpour [1 ]
Rajabi, Ali [1 ]
Emami, Ali [2 ]
Tayefeh-Gholami, Samaneh [1 ]
Teimourian, Shahram [3 ]
Nargesi, Mirsaed Miri [4 ]
Banan-Khojasteh, Seyed Mahdi [1 ]
Safaralizadeh, Reza [1 ]
机构：
[1] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran
[2] Univ Montreal, Dept Biochem & Mol Med, Med Sch, Montreal, PQ, Canada
[3] Iran Univ Med Sci IUMS, Sch Med, Dept Med Genet, Tehran, Iran
[4] Auckland City Hosp, Dept Pathol & Lab Med, Te Whatu Ora Hlth, Auckland, New Zealand
来源：
BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 10-12期
关键词：
biomarker; gastric cancer; miR-362-3p; miR-362-5p; miR-363-5p; CELLS; PROLIFERATION; PROGRESSION; MIGRATION; INVASION; CPEB4;
D O I：
10.1080/17520363.2024.2352419
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: MicroRNAs can be regarded as biomarkers for gastric cancer (GC) diagnosis in the early stages. This study assesses the expression levels of miR-362-3p, miR-362-5p and miR-363-5p as potential biomarkers for GC. Materials & methods: The expression levels of the miRNAs in 90 pairs of GC and adjacent normal tissue samples were analyzed by quantitative real-time reverse transcription PCR (qRT-PCR) and some bioinformatics tools were utilized for analyzing the target genes and possible molecular pathways in which these miRNAs participate. Results & conclusion: There was a significant overexpression of the miRNAs in GC cells and an outstanding correlation between their overexpression with some clinicopathological features of the patients.
引用
收藏
页码：567 / 579
页数：13
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