Three possible diagnostic biomarkers for gastric cancer: miR-362-3p, miR-362-5p and miR-363-5p

被引：1

作者：

Aydinlou, Zahra Hassanpour ^{[1
]}

Rajabi, Ali ^{[1
]}

Emami, Ali ^{[2
]}

Tayefeh-Gholami, Samaneh ^{[1
]}

Teimourian, Shahram ^{[3
]}

Nargesi, Mirsaed Miri ^{[4
]}

Banan-Khojasteh, Seyed Mahdi ^{[1
]}

Safaralizadeh, Reza ^{[1
]}

机构：

[1] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran

[2] Univ Montreal, Dept Biochem & Mol Med, Med Sch, Montreal, PQ, Canada

[3] Iran Univ Med Sci IUMS, Sch Med, Dept Med Genet, Tehran, Iran

[4] Auckland City Hosp, Dept Pathol & Lab Med, Te Whatu Ora Hlth, Auckland, New Zealand

来源：

BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 10-12期

关键词：

biomarker; gastric cancer; miR-362-3p; miR-362-5p; miR-363-5p; CELLS; PROLIFERATION; PROGRESSION; MIGRATION; INVASION; CPEB4;

D O I：

10.1080/17520363.2024.2352419

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: MicroRNAs can be regarded as biomarkers for gastric cancer (GC) diagnosis in the early stages. This study assesses the expression levels of miR-362-3p, miR-362-5p and miR-363-5p as potential biomarkers for GC. Materials & methods: The expression levels of the miRNAs in 90 pairs of GC and adjacent normal tissue samples were analyzed by quantitative real-time reverse transcription PCR (qRT-PCR) and some bioinformatics tools were utilized for analyzing the target genes and possible molecular pathways in which these miRNAs participate. Results & conclusion: There was a significant overexpression of the miRNAs in GC cells and an outstanding correlation between their overexpression with some clinicopathological features of the patients.

引用

页码：567 / 579

页数：13

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