Three possible diagnostic biomarkers for gastric cancer: miR-362-3p, miR-362-5p and miR-363-5p

被引：1

作者：

Aydinlou, Zahra Hassanpour ^{[1
]}

Rajabi, Ali ^{[1
]}

Emami, Ali ^{[2
]}

Tayefeh-Gholami, Samaneh ^{[1
]}

Teimourian, Shahram ^{[3
]}

Nargesi, Mirsaed Miri ^{[4
]}

Banan-Khojasteh, Seyed Mahdi ^{[1
]}

Safaralizadeh, Reza ^{[1
]}

机构：

[1] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran

[2] Univ Montreal, Dept Biochem & Mol Med, Med Sch, Montreal, PQ, Canada

[3] Iran Univ Med Sci IUMS, Sch Med, Dept Med Genet, Tehran, Iran

[4] Auckland City Hosp, Dept Pathol & Lab Med, Te Whatu Ora Hlth, Auckland, New Zealand

来源：

BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 10-12期

关键词：

biomarker; gastric cancer; miR-362-3p; miR-362-5p; miR-363-5p; CELLS; PROLIFERATION; PROGRESSION; MIGRATION; INVASION; CPEB4;

D O I：

10.1080/17520363.2024.2352419

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: MicroRNAs can be regarded as biomarkers for gastric cancer (GC) diagnosis in the early stages. This study assesses the expression levels of miR-362-3p, miR-362-5p and miR-363-5p as potential biomarkers for GC. Materials & methods: The expression levels of the miRNAs in 90 pairs of GC and adjacent normal tissue samples were analyzed by quantitative real-time reverse transcription PCR (qRT-PCR) and some bioinformatics tools were utilized for analyzing the target genes and possible molecular pathways in which these miRNAs participate. Results & conclusion: There was a significant overexpression of the miRNAs in GC cells and an outstanding correlation between their overexpression with some clinicopathological features of the patients.

引用

页码：567 / 579

页数：13

共 50 条

[1] miR-362-3p suppresses ovarian cancer by inhibiting LRP8
Li, Chun
Yang, Yi
Wang, Huimin
Song, Yu
Huang, Huan
TRANSLATIONAL ONCOLOGY, 2022, 15 (01):
[2] The suppressive role of miR-362-3p in epithelial ovarian cancer
Yuan, Jialing
Li, Tao
Yi, Ke
Hou, Minmin
HELIYON, 2020, 6 (07)
[3] MiR-21-3p and miR-21-5p in tumor tissue as diagnostic biomarkers for gastric cancer
Xu, Wen
Yang, Muqing
Gao, Ming
Wu, Wei
Fei, Zhewei
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (07): : 7195 - 7201
[4] MiR-362-3p functions as a tumor suppressor through targeting MCM5 in cervical adenocarcinoma
Wang, Dan
Wang, Hongyan
Li, Yichun
Li, Qian
BIOSCIENCE REPORTS, 2018, 38
[5] The expression levels of miR-655-3p, miR127-5p, miR-369-3p, miR-544a in gastric cancer
Alsaadoni, Hani
Caykara, Burcu
Pence, Sadrettin
Pence, Halime Hanim
Bademler, Suleyman
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2019, 44 (04): : 487 - 491
[6] Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p
Zeng, Jun-Hui
Li, Hong-Ji
Liu, Kun
Liang, Chi-Qian
Wu, Hai-Yan
Chen, Wu-Yun
Tang, Ming-Hui
Zhao, Wan-Ling
Cai, Dong-Qing
Qi, Xu-Feng
DNA AND CELL BIOLOGY, 2023, 42 (07) : 399 - 410
[7] Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells
Ni, Fang
Gui, Zhaohua
Guo, Qiang
Hu, Zhongqian
Wang, Xinyi
Chen, Danlei
Wang, Siying
ONCOLOGY LETTERS, 2016, 11 (02) : 1155 - 1160
[8] MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia
Ma, Qiu-Ling
Wang, Jing-Han
Yang, Min
Wang, Huan-ping
Jin, Jie
JOURNAL OF TRANSLATIONAL MEDICINE, 2018, 16
[9] Long Noncoding RNA XIST Acts as a ceRNA of miR-362-5p to Suppress Breast Cancer Progression
Liu, Baoyin
Luo, Chengyu
Lin, Hua
Ji, Xiaoxin
Zhang, Enyu
Li, Xin
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2021, 36 (06) : 456 - 466
[10] Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p, and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study
Janiczek-Polewska, Marlena
Kolenda, Tomasz
Poter, Paulina
Kozlowska-Maslon, Joanna
Jagiello, Inga
Regulska, Katarzyna
Malicki, Julian
Marszalek, Andrzej
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (15)

← 1 2 3 4 5 →