Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery

被引：1

作者：

Fernandes, Guilherme F. S. ^{[1
,2
]}

Kim, Seong-Heun ^{[3
]}

Castagnolo, Daniele ^{[1
]}

机构：

[1] UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England

[2] UCL, Sch Pharm, 29 39 Brunswick Sq, London WC1N 1AX, England

[3] Kings Coll London, Sch Canc & Pharmaceut Sci, Inst Pharmaceut Sci, 150 Stamford St, London SE1 9NH, England

来源：

RSC ADVANCES | 2024年 / 14卷 / 41期

关键词：

PERIPHERAL MODIFICATIONS; ENANTIOMERICALLY PURE; ENZYMATIC-SYNTHESIS; VANCOMYCIN; ANTIBACTERIAL; DERIVATIVES; INHIBITORS; CHEMISTRY; REDESIGN; ESKAPE;

D O I：

10.1039/d4ra04824e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes. This review explores the application of biocatalysis in the early-stage synthesis of antimicrobial compounds, emphasizing its advantages over traditional chemical methods. We discuss various biocatalysts, including enzymes and whole-cell systems, and their role in the selective functionalization and preparation of antimicrobials and antibacterial building blocks. The review underscores the potential of biocatalysis to advance the development of new antibiotics and suggests directions and potential applications of enzymes in drug development. Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes.

引用

页码：30396 / 30410

页数：15

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