18F-FDG PET/CT in Pediatric ALK-Positive Histiocytosis With Isolated CNS Involvement

被引：0
|
作者：
Singh, Karan [1 ]
London, Kevin [2 ]
Ryan, Jessica [3 ]
Wright, Dale C. [4 ,5 ]
Moghimi, Ali [6 ,7 ]
机构：
[1] Childrens Hosp Westmead, Sydney Childrens Hosp Network, Dept Nucl Med, Westmead, NSW 4001, Australia
[2] Univ Sydney, Fac Med & Hlth, Sydney Sch Hlth Sci, Discipline Med Imaging Sci, Sydney, NSW, Australia
[3] Childrens Hosp Westmead, Canc Ctr Children, Westmead, NSW, Australia
[4] Childrens Hosp Westmead, Sydney Genome Diagnost, Cytogenet, Westmead, NSW, Australia
[5] Univ Sydney, Fac Med & Hlth, Specialty Genom Med, Sydney, NSW, Australia
[6] Childrens Hosp Westmead, Dept Histopathol, Westmead, NSW, Australia
[7] Univ Sydney, Childrens Hosp Westmead, Fac Med & Hlth, Clin Sch, Westmead, NSW, Australia
来源：
CLINICAL NUCLEAR MEDICINE | 2024年 / 49卷 / 10期
关键词：
ALK-positive histiocytosis; pediatrics; FDG PET/CT;
D O I：
10.1097/RLU.0000000000005302
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
An 11-year-old girl presented with focal impaired awareness seizures. MRI brain demonstrated a T2 hyperintense cortical lesion in the left temporal lobe with surrounding vasogenic edema.F- 18-FDG PET/CT was arranged to assess metabolic activity of the cerebral lesion, to screen the whole body for other metabolically active lesions, and to assist biopsy planning. The study demonstrated intensely increased FDG uptake within the left temporal lobe lesion without evidence of hypermetabolic lesions elsewhere on the whole-body acquisition. The brain lesion was excised, and histopathology and molecular testing were consistent with ALK-positive histiocytosis.
引用
收藏
页码：e506 / e508
页数：3
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