At CRYPTO 2023, Boura et al. proposed a new cryptanalysis technique, differential meet-in-the-middle (MITM) attack. They used MITM technique to make the key recovery step of a differential attack more efficient. In this study, a quantum differential meet-in-the-middle attack is proposed by using nested quantum search algorithm, which can achieve up to a quadratic speed-up compared to the classical version. Besides, the time complexity of the attack can be reduced by at least a factor of 2(kin boolean OR kout-n)/2${2<^>{({\left| {{k_{in}} \cup {k_{out}}} \right| } - n)/2}}$ (kin boolean OR kout${{\left| {{k_{in}} \cup {k_{out}}} \right| }}$ is the guessed key length and n$n$ is the block size) compared to the first quantum differential attack proposed by Kaplan et al. at ToSC 2016. Finally, to demonstrate the efficiency of our attack, it is applied to two reduced-round lightweight block ciphers, PIPO and SIMON, to evaluate their post-quantum security. When attacking the same number of rounds, the time complexity of our attack is significantly lower than that of classical attacks. For the 8-round PIPO-128, the attack significantly improves efficiency, reducing the time complexity from 264+260.94$2<^>{64} + 2<^>{60.94}$ to 260.48$2<^>{60.48}$, cutting down the required qRAM size by a factor of 214$2<^>{14}$ and obtaining the data complexity 257$2<^>{57}$ instead of 264$2<^>{64}$ compared to the best quantum attack proposed by Schrottenloher at CRYPTO 2023. For the 19-round SIMON-32-64, the time complexity here will be 231.68$2<^>{31.68}$ instead of 233.39$2<^>{33.39}$ compared to the other quantum attack, and the attack can target more rounds than using Grover-meets-Simon technique. The development of quantum computing drives a shift in cryptanalysis. Many quantum cryptanalysis techniques are proposed. This study proposes a new quantum cryptanalysis technique, quantum differential meet-in-the-middle (QDMITM) attack, which is based on nested quantum search algorithm. And its quantum circuit is shown in the cover graphic. image