Evaluation of Anatomical and Tomographic Biomarkers as Predictive Visual Acuity Factors in Eyes with Retinal Vein Occlusion Treated with Dexamethasone Implant

被引:0
|
作者
Covello, Giuseppe [1 ]
Maglionico, Maria Novella [1 ]
Figus, Michele [1 ,2 ]
Busoni, Chiara [1 ]
Sartini, Maria Sole [2 ]
Lupidi, Marco [3 ,4 ]
Posarelli, Chiara [1 ,2 ]
机构
[1] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, I-56126 Pisa, Italy
[2] Azienda Osped Univ Pisana, Dept Med & Surg Specialties, Ophthalmol, I-56124 Pisa, Italy
[3] Polytech Univ Marche, Dept Expt & Clin Med, Eye Clin, I-60131 Ancona, Italy
[4] Univ Eye Clin, Fdn Macula Onlus, Dipartimento Neurosci Riabilitaz Oftalmol Genet &, I-16132 Genoa, Italy
关键词
retinal vein occlusion; macular edema; OCT; EZD; ELM; DRIL; MI; MACULAR EDEMA SECONDARY; INTRAVITREAL AFLIBERCEPT INJECTION; FOVEAL PHOTORECEPTOR LAYER; INNER LAYERS; INTEGRITY; DISORGANIZATION; ASSOCIATION;
D O I
10.3390/jcm13154533
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: This prospective study evaluated the impact of anatomical and tomographic biomarkers on clinical outcomes of intravitreal dexamethasone implants in patients with macular edema secondary to retinal vein occlusion (RVO). Methods: The study included 46 patients (28 with branch RVO (BRVO) and 18 with central RVO (CRVO)). Best corrected visual acuity (BCVA) significantly improved from a mean baseline of 0.817 +/- 0.220 logMAR to 0.663 +/- 0.267 logMAR at six months and 0.639 +/- 0.321 logMAR at twelve months (p < 0.05). Central retinal thickness (CRT) showed a significant reduction from 666.2 +/- 212.2 <mu>m to 471.1 +/- 215.6 mu m at six months and 467 +/- 175.7 mu m at twelve months (p < 0.05). No significant differences were found in OCT biomarkers between baseline and follow-ups. Results: The study analysed improvements in visual acuity relative to baseline biomarkers. At six months, ellipsoid zone disruption (EZD) was significant for all subgroups. Disorganization of retinal inner layers (DRIL), external limiting membrane (ELM) disruption, macular ischemia (MI), CRT, and BRVO showed significance for any improvement, while DRIL and ELM were significant for changes greater than 0.3 logMAR (p < 0.05). At twelve months, EZD remained significant for all subgroups. ELM, MI, CRT, and BRVO were significant for any improvement, while MI and BRVO were significant for changes greater than 0.3 logMAR (p < 0.05). Hyperreflective foci were not statistically significant at either time point (p > 0.05). Conclusions: The regression model suggested that MI and CRVO could be negative predictive factors for visual outcomes, while ELM and EZD were associated with BCVA improvement one-year post-treatment.
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页数:11
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