Biological function of type 1 regulatory cells and their role in type 1 diabetes

被引：0
|
作者：
Qi, Lingli [1 ]
Wang, Zhichao [2 ]
Huang, Xinxing [1 ]
Gao, Xiuzhu [3 ]
机构：
[1] First Hosp Jilin Univ, Childrens Med Ctr, Dept Gastroenterol, Changchun, Peoples R China
[2] First Hosp Jilin Univ, Childrens Med Ctr, Dept Surg, Changchun, Peoples R China
[3] First Hosp Jilin Univ, Dept Publ Lab Platform, Changchun, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 17期
关键词：
Autoimmune disease; Biological function; Cell therapy; Type; 1; diabetes; Type 1 regulatory cell; CD4(+) T-CELLS; TR1; CELLS; B-CELLS; INTERLEUKIN-10; RESPONSES; FOXP3(-); IL-10; SUPPRESSION; PANCREAS; RECEPTOR;
D O I：
10.1016/j.heliyon.2024.e36524
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The collapse of immune homeostasis induces type 1 diabetes (T1D). In T1D, uncontrolled immune attacks against islet (3 cells reduce insulin secretion, resulting in hyperglycaemia and various complications. Type 1 regulatory (Tr1) cell therapy is a promising approach for the treatment of T1D. Tr1 cells are a subset of regulatory T (Treg) cells that are characterised by high interleukin10 secretion and forkhead box protein P3 non-expression. Tr1 cells are reduced and have impaired function in patients with T1D. Immunotherapy is used to treat various diseases, and Treg cells have been applied to treat T1D in animal models and clinical trials. However, the safety and efficacy of Tr1 cells in treating diabetes and other diseases remain unclear. In this review, we aim to investigate the identification and biological function of Tr1 cells and related studies on immune diseases; additionally, we discuss the feasibility, limitations, and possible solutions of Tr1 cell therapy in T1D. This review shows that T1D is caused by an immune imbalance where defective Tr1 cells fail to control effector T cells, leading to the destruction of islet (3 cells. However, Tr1 cell therapy is safe and effective for other immune diseases, suggesting its potential for treating T1D.
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页数：9
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