Fabrication of Cu-BTC@PW12/GO for multivariate sensing dopamine and acetaminophen as electrochemical sensor

Dopamine (DA) and acetaminophen (AP) are closely associated with many physiological and pathological processes, monitoring their levels precisely is of significance in the early diagnosis of diseases. Herein, a polyoxometalate-based metal-organic framework (POMOF) based on phosphotungstate (Cu-BTC@PW12) was immobilized on graphene oxide (GO) to fabricate Cu-BTC@PW12/GO (CPG) as an electrochemical sensor for the quantification of DA and AP. The spatial confinement effect of copper-based MOF (Cu-BTC) remained the catalytic activity phosphotungstate (PW12) avoiding the aggregation, facilitating electro-catalysis performance for detection of DA and AP. The CPG electrochemical sensor achieved the analysis of DA and AP with the limit of detection (LOD) of 24.8 nM and 62.3 nM, respectively. Furthermore, CPG can be applied for the quantification of DA and AP in real human serum and environmental water samples with satisfied recoveries. Therefore, this work expanded the utilization of POMOF in electrochemical analysis and has promising prospects for the early diagnosis of diseases and environmental treatment.