Impact of Different Red Blood Cell Storage Solutions and Conditions on Cell Function and Viability: A Systematic Review

被引:6
|
作者
Tran, Linh Nguyen T. [1 ]
Gonzalez-Fernandez, Cristina [1 ,2 ]
Gomez-Pastora, Jenifer [1 ]
机构
[1] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA
[2] Univ Cantabria, Chem & Biomol Engn Dept, Avda Los Castros S-N, Santander 39005, Spain
关键词
red blood cells (RBCs); storage solution; storage lesion; blood banking; storage conditions; ADDITIVE SOLUTIONS; IN-VITRO; WHOLE-BLOOD; COLD-STORAGE; ROOM-TEMPERATURE; REJUVENATION; METABOLOMICS; METABOLISM; QUALITY; LESION;
D O I
10.3390/biom14070813
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Red blood cell (RBC) storage solutions have evolved significantly over the past decades to optimize the preservation of cell viability and functionality during hypothermic storage. This comprehensive review provides an in-depth analysis of the effects of various storage solutions and conditions on critical RBC parameters during refrigerated preservation. A wide range of solutions, from basic formulations such as phosphate-buffered saline (PBS), to advanced additive solutions (ASs), like AS-7 and phosphate, adenine, glucose, guanosine, saline, and mannitol (PAGGSM), are systematically compared in terms of their ability to maintain key indicators of RBC integrity, including adenosine triphosphate (ATP) levels, morphology, and hemolysis. Optimal RBC storage requires a delicate balance of pH buffering, metabolic support, oxidative damage prevention, and osmotic regulation. While the latest alkaline solutions enable up to 8 weeks of storage, some degree of metabolic and morphological deterioration remains inevitable. The impacts of critical storage conditions, such as the holding temperature, oxygenation, anticoagulants, irradiation, and processing methods, on the accumulation of storage lesions are also thoroughly investigated. Personalized RBC storage solutions, tailored to individual donor characteristics, represent a promising avenue for minimizing storage lesions and enhancing transfusion outcomes. Further research integrating omics profiling with customized preservation media is necessary to maximize post-transfusion RBC survival and functions. The continued optimization of RBC storage practices will not only enhance transfusion efficacy but also enable blood banking to better meet evolving clinical needs.
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页数:28
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