Improving the efficacy of immunotherapy for colorectal cancer: Targeting tumor microenvironment-associated immunosuppressive cells

被引：1

作者：

Zou, Daoyang ^{[1
]}

Xin, Xi ^{[2
]}

Xu, Yunxian ^{[1
]}

Xu, Huangzhen ^{[1
]}

Huang, Linyan ^{[1
]}

Xu, Tianwen ^{[1
]}

机构：

[1] Fujian Med Univ, Affiliated Hosp 2, Quanzhou 362000, Peoples R China

[2] Ganzhou Peoples Hosp, Ganzhou 341000, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 16期

关键词：

SUPPRESSOR-CELLS; DENDRITIC CELLS; IMMUNE ESCAPE; T-CELLS; STROMAL CELLS; PROGRESSION; NEUTROPHILS; MACROPHAGES; ACTIVATION; RESPONSES;

D O I：

10.1016/j.heliyon.2024.e36446

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Currently, immune checkpoint inhibitors (ICIs) have changed the treatment paradigm for many malignant tumors. As the most common digestive tract malignancy, colorectal cancer (CRC) shows a good response to ICIs only in a small subset of patients with MSI-H/dMMR CRC. In contrast, patients with MSS/pMMR CRC show minimal response to ICIs. The results of the REGONIVO study suggest that targeting the tumor microenvironment (TME) to improve immunotherapy outcomes in MSS/pMMR CRC patients is a feasible strategy. Therefore, this article focuses on exploring the feasibility of targeting the TME to enhance immunotherapy outcomes in CRC, collecting recent basic research on targeting the TME to enhance immunotherapy outcomes in CRC and analyzing ongoing clinical trials to provide a theoretical basis and future research directions for improving immunotherapy outcomes in MSS/pMMR CRC.

引用

页数：11

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