Original antigenic sin: A potential double-edged effect for vaccine improvement

被引:3
作者
Ding, Xuan [1 ,2 ,3 ]
Zhao, Feijun [1 ,2 ,3 ,4 ]
Liu, Zhaoping [1 ,2 ,3 ]
Yao, Jiangchen [1 ,2 ,3 ]
Yu, Han [1 ,2 ,3 ]
Zhang, Xiaohong [1 ,2 ,3 ]
机构
[1] Univ South China, Hengyang Med Coll, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Peoples R China
[2] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China
[3] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China
[4] Univ South China, Affiliated Hosp 1, Lab Med Ctr, Hengyang 421001, Peoples R China
基金
中国国家自然科学基金;
关键词
Original antigenic sin; Cross-reactivity; Immune evasion; Vaccine; CROSS-REACTIVE B; DENGUE VIRUS; ANTIBODY-RESPONSES; SOMATIC MUTATION; INFECTION; IMMUNOGENICITY; MEMORY; PATHOGENESIS; IMMUNITY; PROTEIN;
D O I
10.1016/j.biopha.2024.117187
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Original antigenic sin (OAS) influences the immune response to subsequent infections with related variants following initial pathogen exposure. This phenomenon is characterized by cross-reactivity, which, although it may worsen infections, also provides a degree of protection against immune evasion caused by variations. This paradox complicates the development of creating universal vaccinations, as they frequently show diminished effectiveness against these emerging variants. This review aims to elucidate the diverse impacts of OAS on the immune response to various infections, emphasizing the complicated balance between beneficial and harmful outcomes. Moreover, we evaluate the influence of adjuvants and other variables on the extent of OAS, hence affecting the effectiveness of vaccines. Understanding the mechanisms of OAS that cause persistent infections and evasion of the immune system is crucial for the developing innovative vaccines. And it has significant potential for clinical applications.
引用
收藏
页数:7
相关论文
共 68 条
[1]  
Aguilar-Bretones Muriel, 2023, J Clin Invest, V133, DOI 10.1172/JCI162192
[2]   Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19 [J].
Aguilar-Bretones, Muriel ;
Westerhuis, Brenda M. ;
Raadsen, Matthijs P. ;
de Bruin, Erwin ;
Chandler, Felicity D. ;
Okba, Nisreen M. A. ;
Haagmans, Bart L. ;
Langerak, Thomas ;
Endeman, Henrik ;
van den Akker, Johannes P. C. ;
Gommers, Diederik A. M. P. J. ;
van Gorp, Eric C. M. ;
GeurtsvanKessel, Corine H. ;
de Vries, Rory D. ;
Fouchier, Ron A. M. ;
Rockx, Barry H. G. ;
Koopmans, Marion P. G. ;
van Nierop, Gijsbert P. .
JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (21)
[3]   Safety and immunogenicity of a hybrid-type vaccine booster in BBIBP-CorV recipients in a randomized phase 2 trial [J].
Al Kaabi, Nawal ;
Yang, Yun Kai ;
Du, Li Fang ;
Xu, Ke ;
Shao, Shuai ;
Liang, Yu ;
Kang, Yun ;
Su, Ji Guo ;
Zhang, Jing ;
Yang, Tian ;
Hussein, Salah ;
ElDein, Mohamed Saif ;
Yang, Sen Sen ;
Lei, Wenwen ;
Gao, Xue Jun ;
Jiang, Zhiwei ;
Cong, Xiangfeng ;
Tan, Yao ;
Wang, Hui ;
Li, Meng ;
Mekki, Hanadi Mekki ;
Zaher, Walid ;
Mahmoud, Sally ;
Zhang, Xue ;
Qu, Chang ;
Liu, Dan Ying ;
Yang, Mengjie ;
Eltantawy, Islam ;
Hou, Jun Wei ;
Lei, Ze Hua ;
Xiao, Peng ;
Wang, Zhao Nian ;
Yin, Jin Liang ;
Mao, Xiao Yan ;
Zhang, Jin ;
Qu, Liang ;
Zhang, Yun Tao ;
Yang, Xiao Ming ;
Wu, Guizhen ;
Li, Qi Ming .
NATURE COMMUNICATIONS, 2022, 13 (01)
[4]   Immune history profoundly affects broadly protective B cell responses to influenza [J].
Andrews, Sarah F. ;
Huang, Yunping ;
Kaur, Kaval ;
Popova, Lyubov I. ;
Ho, Irvin Y. ;
Pauli, Noel T. ;
Dunand, Carole J. Henry ;
Taylor, William M. ;
Lim, Samuel ;
Huang, Min ;
Qu, Xinyan ;
Lee, Jane-Hwei ;
Salgado-Ferrer, Marlene ;
Krammer, Florian ;
Palese, Peter ;
Wrammert, Jens ;
Ahmed, Rafi ;
Wilson, Patrick C. .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (316)
[5]   A perspective on potential antibody-dependent enhancement of SARS-CoV-2 [J].
Arvin, Ann M. ;
Fink, Katja ;
Schmid, Michael A. ;
Cathcart, Andrea ;
Spreafico, Roberto ;
Havenar-Daughton, Colin ;
Lanzavecchia, Antonio ;
Corti, Davide ;
Virgin, Herbert W. .
NATURE, 2020, 584 (7821) :353-363
[6]   Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients [J].
Baraniak, Ilona ;
Kern, Florian ;
Holenya, Pavlo ;
Griffiths, Paul ;
Reeves, Matthew .
JOURNAL OF INFECTIOUS DISEASES, 2019, 220 (02) :228-232
[7]   The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity [J].
Beltramello, Martina ;
Williams, Katherine L. ;
Simmons, Cameron P. ;
Macagno, Annalisa ;
Simonelli, Luca ;
Quyen, Nguyen Than Ha ;
Sukupolvi-Petty, Soila ;
Navarro-Sanchez, Erika ;
Young, Paul R. ;
de Silva, Aravinda M. ;
Rey, Felix A. ;
Varani, Luca ;
Whitehead, Stephen S. ;
Diamond, Michael S. ;
Harris, Eva ;
Lanzavecchia, Antonio ;
Sallusto, Federica .
CELL HOST & MICROBE, 2010, 8 (03) :271-283
[8]   Analysis of the original antigenic sin antibody response to the major outer membrane protein of Chlamydia trachomatis [J].
Berry, JD ;
Peeling, RW ;
Brunham, RC .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (01) :180-186
[9]   Bivalent COVID-19 Vaccines: Can the Original Antigenic Sin Be Forgiven? [J].
Blankson, Joel N. .
JOURNAL OF INFECTIOUS DISEASES, 2023, 227 (11) :1221-1223
[10]   Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19 [J].
Brown, Eric L. ;
Essigmann, Heather T. .
MSPHERE, 2021, 6 (02) :1-6