Melanocortin-1 receptor ( MC1R ): a review for dermatologists

被引：0
作者：
Guida, Stefania [1 ,2 ]
Puig, Susana [3 ]
DI Resta, Chiara [2 ,4 ]
Sallustio, Fabio [5 ]
Mangano, Eleonora [6 ]
Stabile, Giorgio [1 ,2 ]
Longo, Caterina [7 ,8 ]
Pellacani, Giovanni [9 ]
Guida, Gabriella [10 ]
Rongioletti, Franco [1 ,2 ]
机构：
[1] IRCCS San Raffaele Hosp, Dermatol Clin, Milan, Italy
[2] Univ Vita Salute San Raffaele, Fac Med, Via Olgettina 58, I-20132 Milan, Italy
[3] Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed august Pi i Sunye, Melanoma Unit,Dept Dermatol, Barcelona, Spain
[4] IRCCS San Raffaele Hosp, Genom Unit Diag Human Pathol, Milan, Italy
[5] Aldo Moro Univ Bari, Dept Interdisciplinary Med, Bari, Italy
[6] Natl Res Ctr CNR, Inst Biomed Technol ITB, Milan, Italy
[7] Univ Modena & Reggio Emilia, Dept Dermatol, Modena, Italy
[8] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Skin Canc Ctr, Reggio Emilia, Italy
[9] Sapienza Univ Rome, Dept Dermatol, Rome, Italy
[10] Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Sect Mol Biol, Bari, Italy
来源：
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY | 2024年 / 159卷 / 03期
关键词：
Human MC1R protein; Melanoma; Skin aging; Skin neoplasms; MC1R GENE VARIANTS; MELANOMA RISK; CUTANEOUS MELANOMA; POOLED ANALYSIS; RED HAIR; DERMOSCOPIC FEATURES; SPORADIC MELANOMA; FAIR SKIN; EXPRESSION; ASSOCIATION;
D O I：
10.23736/S2784-8671.24.07839-3
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Melanocortin-1 receptor ( MC1R ) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non -pigmentary pathways related to DNA -repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin. Specifically, after summarizing the current knowledge about MC1R structure and polymorphisms, we report data concerning the correlation between MC1R , phenotypic traits, skin aging, other diseases and skin cancers and their risk assessment through genetic testing.
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收藏
页码：285 / 293
页数：9
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