Natural Bioactives and their Nano-formulations for Management of Acne Vulgaris: A Comprehensive Review

Managing acne presents a multifaceted challenge for teenagers, impacting their physical appearance and emotional well-being. The multifactorial nature of acne, which involves hyperactive oil glands, follicular hyperkeratinization, bacterial activity, and inflammation, emphasizes the importance of effective treatment strategies. This review provides a comprehensive overview of the role of natural bio-actives and their Nano-formulations in addressing acne. Additionally, this review highlights numerous anti-acne formulations composed of natural components and the methods used to formulate Nano-formulations with anti-acne properties. Potential mechanisms of action for natural elements used in Nano-formulations, such as aloe Vera, green tea extract, grape extract, cucumber extract, lavender essential oil, and tea tree oil, are explored. These natural components contain phytoconstituents that play key roles in skin repair and the treatment of several skin conditions, such as acne, aging, UV-induced skin damage, surgical wounds, psoriasis, and eczema. Furthermore, the review discusses patents filed for acne treatment using natural components and addresses challenges in formulating anti-acne products such as quality, availability, cost, and method validations.