Genetics of type-1 diabetes

被引：0

作者：

Ikegami, Hiroshi ^{[1
,2
]}

Noso, Shinsuke ^{[3
]}

机构：

[1] Kindai Univ, Osaka, Japan

[2] Osaka Head Off, Nikkei Inc, Human Resources, Director Hlth Adm Ctr & Nikkei Clin, Osaka, Japan

[3] Kindai Univ, Fac Med, Dept Endocrinol Metab & Diabet, Osaka, Sayama, Japan

来源：

DIABETOLOGY INTERNATIONAL | 2024年 / 15卷 / 04期

关键词：

LYMPHOID TYROSINE PHOSPHATASE; INSULIN GENE; CLASS-II; SUSCEPTIBILITY LOCUS; DIAGNOSTIC-CRITERIA; DIABETOGENIC GENE; ALLELIC VARIATION; JAPANESE FAMILY; HUMAN THYMUS; MELLITUS;

D O I：

10.1007/s13340-024-00754-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type-1 diabetes is a multifactorial disease characterized by genetic and environmental factors that contribute to its development and progression. Despite progress in the management of type-1 diabetes, the final goal of curing the disease is yet to be achieved. To establish effective methods for the prevention, intervention, and cure of the disease, the molecular mechanisms and pathways involved in its development and progression should be clarified. One effective approach is to identify genes responsible for disease susceptibility and apply information obtained from the function of genes in disease etiology for the protection, intervention, and cure of type-1 diabetes. In this review, we discuss the genetic basis of type-1 diabetes, along with prospects for its prevention, intervention, and cure for type-1 diabetes.

引用

页码：688 / 698

页数：11