Multidrug-Resistant Bacteria in Immunocompromised Patients

被引:0
|
作者
Duhaniuc, Alexandru [1 ,2 ]
Paduraru, Diana [3 ]
Nastase, Eduard-Vasile [4 ,5 ]
Trofin, Felicia [1 ]
Iancu, Luminia-Smaranda [1 ,2 ]
Sima, Cristina-Mihaela [1 ,5 ]
Dorneanu, Olivia-Simona [1 ,5 ]
机构
[1] Univ Med & Pharm Grigore T Popa, Dept Prevent Med & Interdisciplinar Microbiol, Iasi 700115, Romania
[2] Natl Inst Publ Hlth Reg Ctr Publ Hlth, Iasi 700465, Romania
[3] Dr CI Parhon Clin Hosp, Iasi 700503, Romania
[4] Univ Med & Pharm Grigore T Popa, Dept Internal Med Infect Dis 2, Iasi 700115, Romania
[5] Clin Hosp Infect Dis Sf Parascheva, Iasi 700116, Romania
关键词
multidrug-resistant bacteria; immunocompromised patients; colonization; infection; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; RISK-FACTORS; COLONIZATION; PREVALENCE; ENTEROCOCCI; INFECTIONS; MORTALITY; CARRIAGE;
D O I
10.3390/ph17091151
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The increasing incidence of antibiotic resistance in bacteria is a major problem in terms of therapeutic options, especially in immunocompromised patients, such as patients from intensive care units (ICUs), HIV-positive patients, patients with malignancies or transplant patients. Commensal bacteria, especially anaerobes, serve to maintain microbial stability by preventing overpopulation with pathogenic bacteria. In immunocompromised patients, microbiota imbalance caused by antibiotic therapy and decreased host immunity favors intestinal overpopulation with pathogenic species, leading to increased bacterial translocation and susceptibility to systemic infections. Infections with multidrug-resistant (MDR) bacteria pose major challenges to the establishment of appropriate treatment and lead to increased mortality. Asymptomatic colonization with MDR bacteria usually precedes infection and tends to persist for long periods of time, and in immunocompromised patients, colonization with MDR bacteria is a risk factor for systemic infections. This review aims to assess the relation between colonization and infection with MDR bacteria in immunocompromised patients such as ICU patients, HIV-positive patients and cancer patients and to identify the prevalence and patterns of MDR bacterial colonization and infection in this category of patients.
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页数:28
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