Liver and bile duct organoids and tumoroids

被引：4

作者：

Luo, Xuanming ^{[1
,2
,3
,4
,5
,6
]}

Gong, Yuda ^{[1
,2
,3
,4
,5
]}

Gong, Zijun ^{[1
,2
,3
,4
,5
]}

Fan, Kun ^{[6
]}

Suo, Tao ^{[1
,2
,3
,4
,5
]}

Liu, Han ^{[1
,2
,3
,4
,5
]}

Ni, Xiaoling ^{[1
,2
,3
,4
,5
]}

Ni, Xiaojian ^{[1
,2
,3
,4
,5
]}

Abudureyimu, Miyesaier ^{[7
]}

Liu, Houbao ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Biliary Surg, Shanghai, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Biliary Tract Dis Ctr, Shanghai, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Canc Ctr, Shanghai, Peoples R China

[4] Fudan Univ, Biliary Tract Dis Inst, Shanghai, Peoples R China

[5] Shanghai Engn Res Ctr Biliary Tract Minimal Invas, Shanghai, Peoples R China

[6] Fudan Univ, Shanghai Xuhui Cent Hosp, Dept Gen Surg, Shanghai, Peoples R China

[7] Fudan Univ, Shanghai Xuhui Cent Hosp, Cardiovasc Dept, Shanghai, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 178卷

关键词：

Organoids; Liver Cancer; Bile Duct Tumors; Embryonic and Adult Tissues; PATIENT-DERIVED ORGANOIDS; PLURIPOTENT STEM-CELLS; IN-VITRO; MOUSE; CULTURE; CANCER; HEPATOCYTES; MODELS; SORAFENIB; RENEWAL;

D O I：

10.1016/j.biopha.2024.117104

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Organoids refer to 3D cultures established to recapitulate histology, pathology, architecture, and genetic traits of various organs and tissues in the body, thereby replacing 2D cell cultures, xenograft, and animal models. Organoids form a 3D in vitro mimic of original tissues like the liver and are derived from embryonic or adult tissue stem cells. Liver and bile duct tumor organoids, also called, tumoroids capture genetic diversity, cellular, and pathophysiological properties of original tumors. Moreover, co-culture techniques along with genetic modulation of organoids allow for using tumoroids in liver and bile duct cancer research and drug screening/ testing. Therefore, tumoroids are promising platforms for studying liver and bile duct cancer, which paves the way for the new era of personalized therapies. In the current review, we aimed to discuss liver and bile duct organoids with special emphasis on tumoroids and their applications, advantages, and shortcomings.

引用

页数：8

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