The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds

被引：140

作者：

Bhol, Nitish Kumar ^{[1
]}

Bhanjadeo, Madhabi Madhusmita ^{[2
]}

Singh, Anup Kumar ^{[3
]}

Dash, Umesh Chandra ^{[4
]}

Ojha, Rakesh Ranjan ^{[5
]}

Majhi, Sanatan ^{[1
]}

Duttaroy, Asim K. ^{[6
]}

Jena, Atala Bihari ^{[3
]}

机构：

[1] Utkal Univ, Post Grad Dept Biotechnol, Bhubaneswar 751004, Odisha, India

[2] KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, Odisha, India

[3] Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, Pune, India

[4] KIIT Deemed Be Univ, KIIT Sch Biotechnol, Environm Biotechnol Lab, Bhubaneswar, Odisha, India

[5] BJB A Coll, Dept Bioinformat, Bhubaneswar 751014, Odisha, India

[6] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Nutr, Oslo, Norway

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 178卷

关键词：

Cytokines; Inflammation; ROS; Antioxidants; Cytokine storms; Infection; Inflammatory disorders; Cancer; Radiation; COVID-19; Inflammatory bowel disease; TUMOR-NECROSIS-FACTOR; INNATE LYMPHOID-CELLS; MACROPHAGE ACTIVATION SYNDROME; ACUTE RESPIRATORY-INFECTION; MONOCLONAL-ANTIBODY; INTERFERON-GAMMA; FACTOR-ALPHA; TNF-ALPHA; VITAMIN-D; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS;

D O I：

10.1016/j.biopha.2024.117177

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cytokines regulate immune responses essential for maintaining immune homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge as promising therapeutic agents because they mitigate oxidative stress and modulate inflammatory pathways. Antioxidants can potentially ameliorate inflammation-related disorders by counteracting excessive cytokinemediated inflammatory responses. A comprehensive understanding of cytokine-mediated inflammatory pathways and the interplay with antioxidants is paramount for developing natural therapeutic agents targeting inflammation-related disorders and helping to improve clinical outcomes and enhance the quality of life for patients. Among these antioxidants, curcumin, vitamin C, vitamin D, propolis, allicin, and cinnamaldehyde have garnered attention for their anti-inflammatory properties and potential therapeutic benefits. This review highlights the interrelationship between cytokines-mediated disorders in various diseases and therapeutic approaches involving antioxidants.

引用

页数：22

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