The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds

被引：42
作者：
Bhol, Nitish Kumar [1 ]
Bhanjadeo, Madhabi Madhusmita [2 ]
Singh, Anup Kumar [3 ]
Dash, Umesh Chandra [4 ]
Ojha, Rakesh Ranjan [5 ]
Majhi, Sanatan [1 ]
Duttaroy, Asim K. [6 ]
Jena, Atala Bihari [3 ]
机构：
[1] Utkal Univ, Post Grad Dept Biotechnol, Bhubaneswar 751004, Odisha, India
[2] KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, Odisha, India
[3] Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, Pune, India
[4] KIIT Deemed Be Univ, KIIT Sch Biotechnol, Environm Biotechnol Lab, Bhubaneswar, Odisha, India
[5] BJB A Coll, Dept Bioinformat, Bhubaneswar 751014, Odisha, India
[6] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Nutr, Oslo, Norway
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 178卷
关键词：
Cytokines; Inflammation; ROS; Antioxidants; Cytokine storms; Infection; Inflammatory disorders; Cancer; Radiation; COVID-19; Inflammatory bowel disease; TUMOR-NECROSIS-FACTOR; INNATE LYMPHOID-CELLS; MACROPHAGE ACTIVATION SYNDROME; ACUTE RESPIRATORY-INFECTION; MONOCLONAL-ANTIBODY; INTERFERON-GAMMA; FACTOR-ALPHA; TNF-ALPHA; VITAMIN-D; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS;
D O I：
10.1016/j.biopha.2024.117177
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cytokines regulate immune responses essential for maintaining immune homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge as promising therapeutic agents because they mitigate oxidative stress and modulate inflammatory pathways. Antioxidants can potentially ameliorate inflammation-related disorders by counteracting excessive cytokinemediated inflammatory responses. A comprehensive understanding of cytokine-mediated inflammatory pathways and the interplay with antioxidants is paramount for developing natural therapeutic agents targeting inflammation-related disorders and helping to improve clinical outcomes and enhance the quality of life for patients. Among these antioxidants, curcumin, vitamin C, vitamin D, propolis, allicin, and cinnamaldehyde have garnered attention for their anti-inflammatory properties and potential therapeutic benefits. This review highlights the interrelationship between cytokines-mediated disorders in various diseases and therapeutic approaches involving antioxidants.
引用
收藏
页数：22
相关论文
共 203 条
  • [1] Role of cytokines in neurological disorders
    Aarli, JA
    [J]. CURRENT MEDICINAL CHEMISTRY, 2003, 10 (19) : 1931 - 1937
  • [2] Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Abbadie, C
    Lindia, JA
    Cumiskey, AM
    Peterson, LB
    Mudgett, JS
    Bayne, EK
    DeMartino, JA
    MacIntyre, DE
    Forrest, MJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) : 7947 - 7952
  • [3] Dysregulation of type I interferon responses in COVID-19
    Acharya, Dhiraj
    Liu, GuanQun
    Gack, Michaela U.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2020, 20 (07) : 397 - 398
  • [4] Emapalumab: First Global Approval
    Al-Salama, Zaina T.
    [J]. DRUGS, 2019, 79 (01) : 99 - 103
  • [5] COMPARISON OF THE ANTI-HERPES SIMPLEX VIRUS ACTIVITIES OF PROPOLIS AND 3-METHYL-BUT-2-ENYL CAFFEATE
    AMOROS, M
    LURTON, E
    BOUSTIE, J
    GIRRE, L
    SAUVAGER, F
    CORMIER, M
    [J]. JOURNAL OF NATURAL PRODUCTS, 1994, 57 (05): : 644 - 647
  • [6] Andersag H., 1939, Pat., Patent No. [DE683692, 683692]
  • [7] Cytokine: more than a new word, a new concept proposed by Stanley Cohen thirty years ago
    不详
    [J]. CYTOKINE, 2004, 28 (06) : 242 - 247
  • [8] Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature
    Antico, Antonio
    Tampoia, Marilina
    Tozzoli, Renato
    Bizzaro, Nicola
    [J]. AUTOIMMUNITY REVIEWS, 2012, 12 (02) : 127 - 136
  • [9] Type 1 diabetes
    Atkinson, Mark A.
    Eisenbarth, George S.
    Michels, Aaron W.
    [J]. LANCET, 2014, 383 (9911) : 69 - 82
  • [10] Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages
    Atreya, Raja
    Zimmer, Michael
    Bartsch, Brigitte
    Waldner, Maximilian J.
    Atreya, Imke
    Neumann, Helmut
    Hildner, Kai
    Hoffman, Arthur
    Kiesslich, Ralf
    Rink, Andreas D.
    Rau, Tilman T.
    Rose-John, Stefan
    Kessler, Hermann
    Schmidt, Jan
    Neurath, Markus F.
    [J]. GASTROENTEROLOGY, 2011, 141 (06) : 2026 - 2038
12345678910