Comparison of the effect of combination therapies in the treatment of large varicose ulcers: A real-world cohort study

被引：0

作者：

Wen, Fangfang ^{[1
]}

Xie, Hailiang ^{[1
]}

Lai, Minggui ^{[1
]}

Zheng, Guofu ^{[1
]}

Xie, Yuancai ^{[1
]}

Liu, Xiaochun ^{[1
]}

机构：

[1] Ganzhou Peoples Hosp, Dept Gen Surg, 17 Hongqi Ave, Ganzhou 341000, Jiangxi, Peoples R China

来源：

SCIENCE PROGRESS | 2024年 / 107卷 / 03期

关键词：

Varicose veins; varicose ulcer; ablation techniques; high ligation; foam sclerotherapy; compression therapy; skin transplantation; ENDOVENOUS LASER-ABLATION; VENOUS LEG ULCERS; RANDOMIZED CLINICAL-TRIAL; HIGH LIGATION; FOAM SCLEROTHERAPY; RISK-FACTORS; COMPRESSION THERAPY; MICROWAVE; OUTCOMES; GUIDELINES;

D O I：

10.1177/00368504241283352

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Objectives: The primary treatment for varicose ulcers is to address the underlying cause of venous hypertension, additionally, split-thickness skin transplantation (ST) is an effective option for large ulcers. The aim of this study was to compare the efficacy of venous surgery with or without split-thickness ST in the management of varicose ulcers (diameter >= 6 cm). Methods: Patients with varicose ulcers between 2013 and 2023 were included in the real-world retrospective cohort study. The endovenous microwave ablation/endovenous laser ablation-high ligation-foam sclerotherapy-compression therapy + ST group (EMA/EVLA-CT-HL-FS + ST) consisted of 32 patients, while the EMA/EVLA-CT-HL-FS group consisted of 48 patients. Results: A difference in ulcer healing time was found between the two groups (the hazard ratio [HR] was 4.4, 95% CI [2.3-8.2], P < 0.0001). However, the healing rate did not differ between the two groups at 6 and 12 months postoperatively. Conclusion: ST has been shown to expedite ulcer healing and ameliorate the symptoms of VVs in the early stages of treatment, while its intermediate to long-term efficacy for ulcer healing and overall patient quality of life may be limited.

引用

页数：14

共 48 条

[1] Foam sclerotherapy [J].

Alder, Glen ;

Lees, Tim .

PHLEBOLOGY, 2015, 30 :18-23

[2] Compression therapy for venous leg ulcers: risk factors for adverse events and complications, contraindications - a review of present guidelines [J].

Andriessen, A. ;

Apelqvist, J. ;

Mosti, G. ;

Partsch, H. ;

Gonska, C. ;

Abel, M. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017, 31 (09) :1562-1568

[3] European College of Phlebology guideline for truncal ablation [J].

Bozkurt, A. Kursat ;

Lawaetz, Martin ;

Danielsson, Gudmundur ;

Lazaris, Andreas M. ;

Pavlovic, Milos ;

Olariu, Sorin ;

Rasmussen, Lars .

PHLEBOLOGY, 2020, 35 (02) :73-83

[4] Pathogenesis of venous ulcer [J].

Comerota, Anthony ;

Lurie, Fedor .

SEMINARS IN VASCULAR SURGERY, 2015, 28 (01) :6-14

[5] European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs [J].

De Maeseneer, Marianne G. ;

Kakkos, Stavros K. ;

Aherne, Thomas ;

Baekgaard, Niels ;

Black, Stephen ;

Blomgren, Lena ;

Giannoukas, Athanasios ;

Gohel, Manjit ;

de Graaf, Rick ;

Hamel-Desnos, Claudine ;

Jawien, Arkadiusz ;

Jaworucka-Kaczorowska, Aleksandra ;

Lattimer, Christopher R. ;

Mosti, Giovanni ;

Noppeney, Thomas ;

Josee van Rijn, Marie ;

Stansby, Gerry ;

Kolh, Philippe ;

Bastos Goncalves, Frederico ;

Chakfe, Nabil ;

Coscas, Raphael ;

de Borst, Gert J. ;

Dias, Nuno, V ;

Hinchliffe, Robert J. ;

Koncar, Igor B. ;

Lindholt, Jes S. ;

Trimarchi, Santi ;

Tulamo, Riikka ;

Twine, Christopher P. ;

Vermassen, Frank ;

Wanhainen, Anders ;

Bjorck, Martin ;

Labropoulos, Nicos ;

Lurie, Fedor ;

Mansilha, Armando ;

Nyamekye, Isaac K. ;

Ramirez Ortega, Marta ;

Ulloa, Jorge H. ;

Urbanek, Tomasz ;

van Rij, Andre M. ;

Vuylsteke, Marc E. .

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2022, 63 (02) :184-267

[6] Comparison of 5-year outcomes and quality of life between endovenous laser (980 nm) and microwave ablation combined with high ligation for varicose veins [J].

Fan, Pengcheng ;

Cong, Longlong ;

Dong, Jian ;

Han, Yang ;

Yang, Lin .

FRONTIERS IN SURGERY, 2022, 9

[7] Endovenous laser ablation with and without high ligation compared with high ligation and stripping in the treatment of great saphenous varicose veins: initial results of a multicentre randomized controlled trial [J].

Flessenkaemper, I. ;

Hartmann, M. ;

Stenger, D. ;

Roll, S. .

PHLEBOLOGY, 2013, 28 (01) :16-23

[8] GRAFTING OF VENOUS LEG ULCERS [J].

GOLDMAN, MP .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1991, 25 (05) :867-868

[9] A randomized controlled noninferiority trial comparing radiofrequency with stripping and conservative hemodynamic cure for venous insufficiency technique for insufficiency of the great saphenous vein [J].

Gonzalez Canas, Elena ;

Florit Lopez, Salvador ;

Vives Vilagut, Roser ;

Alejandro Guevara-Noriega, Kerbi ;

Santos Espi, Marta ;

Rios, Jose ;

Navarro Soto, Salvador ;

Gimenez Gaibar, Antonio .

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS, 2021, 9 (01) :101-112

[10] SPLIT-SKIN GRAFTING OF VARICOSE LEG ULCERS - A SURVEY AND THE IMPORTANCE OF ASSESSMENT OF RISK-FACTORS IN PREDICTING OUTCOME FROM THE PROCEDURE [J].

HARRISON, PV .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1988, 13 (01) :4-6

← 1 2 3 4 5 →