Relationships Between Regeneration,Wound Healing, and Cancer

被引：4

作者：

Maggiore, Gianna ^{[1
,2
,3
]}

Zhu, Hao ^{[1
,2
,3
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Childrens Med Ctr Res Inst, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Childrens Med Ctr Res Inst, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

来源：

ANNUAL REVIEW OF CANCER BIOLOGY | 2024年 / 8卷

关键词：

liver regeneration; wound healing; hepatocellular carcinoma; tissue repair; tumor suppression; STEM-CELLS; IN-VIVO; CLONAL HEMATOPOIESIS; MURINE MODEL; AMBYSTOMA-MEXICANUM; TISSUE REGENERATION; POSITIVE SELECTION; LIVER HOMEOSTASIS; SOMATIC MUTATIONS; EXPOSURE ROUTES;

D O I：

10.1146/annurev-cancerbio-062822-123558

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regeneration and cancer share genetic mechanisms and cellular processes. While highly regenerative cells are often the source of cancer, persistent injury or imperfect regeneration in the form of wound healing can lead to degenerative conditions that favor cancer development. Thus, the causal interplay between regeneration and cancer is complex. This article focuses on understanding how functional variation in regeneration and wound healing might influence the risk of cancer. Variation in regenerative capacity might create trade-offs or adaptations that significantly alter cancer risk. From this perspective, we probe the causal relationships between regeneration, wound healing, and cancer.

引用

页码：177 / 197

页数：21

共 160 条

[1] Epigenetic reprogramming of breast cancer cells with oocyte extracts [J].

Allegrucci, Cinzia ;

Rushton, Michael D. ;

Dixon, James E. ;

Sottile, Virginie ;

Shah, Mansi ;

Kumari, Rajendra ;

Watson, Sue ;

Alberio, Ramiro ;

Johnson, Andrew D. .

MOLECULAR CANCER, 2011, 10

[2] Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis [J].

Ang, Chow Hiang ;

Hsu, Shih Han ;

Guo, Fusheng ;

Tan, Chong Teik ;

Yu, Victor C. ;

Visvader, Jane E. ;

Chow, Pierce K. H. ;

Fu, Nai Yang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (39) :19530-19540

[3] P53 EXPRESSION DURING NORMAL TISSUE REGENERATION IN RESPONSE TO ACUTE CUTANEOUS INJURY IN SWINE [J].

ANTONIADES, HN ;

GALANOPOULOS, T ;

NEVILLEGOLDEN, J ;

KIRITSY, CP ;

LYNCH, SE .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) :2206-2214

[4] Tissue-regeneration program underlies lung-cancer suppression [J].

Attardi, Laura D. ;

Kaiser, Alyssa M. .

NATURE, 2023,

[5]

Baker NE, 2020, NAT REV GENET, V21, P683, DOI 10.1038/s41576-020-0262-8

[6] DNA damage and tissue repair: What we can learn from planaria [J].

Barghouth, Paul G. ;

Thiruvalluvan, Manish ;

LeGro, Melanie ;

Oviedo, Nestor J. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2019, 87 :145-159

[7] Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].

Barker, Nick ;

van Es, Johan H. ;

Kuipers, Jeroen ;

Kujala, Pekka ;

van den Born, Maaike ;

Cozijnsen, Miranda ;

Haegebarth, Andrea ;

Korving, Jeroen ;

Begthel, Harry ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2007, 449 (7165) :1003-U1

[8] Crypt stem cells as the cells-of-origin of intestinal cancer [J].

Barker, Nick ;

Ridgway, Rachel A. ;

van Es, Johan H. ;

van de Wetering, Marc ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

Clarke, Alan R. ;

Sansom, Owen J. ;

Clevers, Hans .

NATURE, 2009, 457 (7229) :608-U119

[9] Ethylnitrosourea induces neoplasia in zebrafish (Danio rerio) [J].

Beckwith, LG ;

Moore, JL ;

Tsao-Wu, GS ;

Harshbarger, JC ;

Cheng, KC .

LABORATORY INVESTIGATION, 2000, 80 (03) :379-385

[10] tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors [J].

Berghmans, S ;

Murphey, RD ;

Wienholds, E ;

Neuberg, D ;

Kutok, JL ;

Fletcher, CDM ;

Morris, JP ;

Liu, TX ;

Schulte-Merker, S ;

Kanki, JP ;

Plasterk, R ;

Zon, LI ;

Look, AT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (02) :407-412

← 1 2 3 4 5 6 7 8 9 10 →