Are Preformed Fibrils a Model of Parkinson's Disease?

被引：1
|
作者：
Woerman, Amanda L. [1 ]
Luk, Kelvin C. [2 ]
机构：
[1] Colorado State Univ, Prion Res Ctr, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA
[2] Univ Penn, Ctr Neurodegenerat Dis Res, Dept Pathol & Lab Med, Philadelphia, PA USA
来源：
JOURNAL OF PARKINSONS DISEASE | 2024年 / 14卷 / 06期
关键词：
Alpha-synuclein; Parkinson's disease; synucleinopathies; ALPHA-SYNUCLEIN;
D O I：
10.3233/JPD-240228
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Pre-formed fibrils (PFFs) made from recombinant a-synuclein are broadly used throughout the field in cellular and animal models of Parkinson's disease. However, their ability to successfully recapitulate disease biology is a controversial topic. In this article, two researchers debate this issue with Amanda Woerman taking the view that PFFs are a model of synucleinopathy but not Parkinson's disease, while Kelvin Luk defends their use as an important tool in the field.
引用
收藏
页码：1095 / 1103
页数：9
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