Unraveling the Immune Microenvironment in Diffuse Large B-Cell Lymphoma: Prognostic and Potential Therapeutic Implications

被引:2
作者
Koumpis, Epameinondas [1 ]
Papoudou-Bai, Alexandra [2 ]
Papathanasiou, Konstantina [1 ]
Kolettas, Evangelos [3 ,4 ]
Kanavaros, Panagiotis [5 ]
Hatzimichael, Eleftheria [1 ]
机构
[1] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Hematol, Ioannina 45500, Greece
[2] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Pathol, Ioannina 45500, Greece
[3] Univ Ioannina, Fac Med, Sch Hlth Sci, Lab Biol, Ioannina 45110, Greece
[4] Fdn Res & Technol, Biomed Res Inst, Ioannina 45110, Greece
[5] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Anat Histol Embryol, Ioannina 45110, Greece
关键词
DLBCL; microenvironment; TME; lymphoma; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; NK CELLS; EXPRESSION; DIFFERENTIATION; RITUXIMAB; SURVIVAL; PROLIFERATION; FOXP3; FIBROBLASTS;
D O I
10.3390/cimb46070420
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diffuse large B cell lymphoma (DLBCL) is a multifaceted condition characterized by significant diversity in its molecular and pathological subtypes and clinical manifestation. Despite the progress made in the treatment of DLBCL through the development of novel drugs, an estimated one-third of patients encounter relapse or acquire refractory disease. The tumor microenvironment (TME) of DLBCL, a complex network consisting of cellular and noncellular components that engage in interactions with the tumor, is a parameter that is gaining increasing attention. The TME comprises both the immune and nonimmune microenvironments. The immune microenvironment comprises natural killer (NK) cells, dendritic cells (DCs), tumor-associated macrophages (TAMs), neutrophils, myeloid-derived suppressor cells (MDSCs), and T and B lymphocytes. The nonimmune microenvironment consists of the extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), mesenchymal stromal cells, and other molecules that are secreted. Despite ongoing research, the exact impact of these components and their interaction on the progression of the disease remains elusive. A comprehensive review of significant discoveries concerning the cellular and noncellular constituents, molecular characteristics, and treatment response and prognosis of the TME in DLBCL, as well as the potential targeting of the TME with novel therapeutic approaches, is provided in this article.
引用
收藏
页码:7048 / 7064
页数:17
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